Prion-based memory of heat stress in yeast

Prion
Tatiana A ChernovaKeith D Wilkinson

Abstract

Amyloids and amyloid-based prions are self-perpetuating protein aggregates which can spread by converting a normal protein of the same sequence into a prion form. They are associated with diseases in humans and mammals, and control heritable traits in yeast and other fungi. Some amyloids are implicated in biologically beneficial processes. As prion formation generates reproducible memory of a conformational change, prions can be considered as molecular memory devices.  We have demonstrated that in yeast, stress-inducible cytoskeleton-associated protein Lsb2 forms a metastable prion in response to high temperature. This prion promotes conversion of other proteins into prions and can persist in a fraction of cells for a significant number of cell generations after stress, thus maintaining the memory of stress in a population of surviving cells. Acquisition of an amino acid substitution required for Lsb2 to form a prion coincides with acquisition of increased thermotolerance in the evolution of Saccharomyces yeast. Thus the ability to form an Lsb2 prion in response to stress coincides with yeast adaptation to growth at higher temperatures. These findings intimately connect prion formation to the cellular response to environmental ...Continue Reading

References

Sep 1, 1988·Yeast·B S CoxC S McLaughlin
Jul 23, 1998·Cell·V V Kushnirov, M D Ter-Avanesyan
Jan 16, 1999·Molecular and Cellular Biology·G P NewnamY O Chernoff
Oct 3, 1999·Methods in Enzymology·T R SerioS L Lindquist
Mar 11, 2000·Molecular Cell·N Sondheimer, S Lindquist
Jun 12, 2002·The Journal of Cell Biology·Anatoli B MeriinMichael Y Sherman
Aug 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Irina L DerkatchSusan W Liebman
Jul 1, 2006·Nature·Motomasa TanakaJonathan S Weissman
Jul 11, 2006·The Journal of Clinical Investigation·Joseph M SavittTed M Dawson
Oct 19, 2006·Methods in Enzymology·Sviatoslav N BagriantsevSusan W Liebman
Apr 7, 2007·Trends in Biochemical Sciences·Douglas M FowlerJeffery W Kelly
May 19, 2007·FEBS Letters·Yury O Chernoff
Dec 11, 2008·PLoS Biology·Jens TyedmersSusan Lindquist
Jul 1, 2007·Prion·Irina L Derkatch, Susan W Liebman
Jan 1, 2007·Prion·M Teresa PastorLuis Serrano
Jan 13, 2010·Neuron·Adriano Aguzzi, Lawrence Rajendran
Mar 2, 2010·Nature Reviews. Drug Discovery·Adriano Aguzzi, Tracy O'Connor
May 7, 2010·Progress in Neurobiology·James A Duce, Ashley I Bush
Feb 15, 2011·Applied and Environmental Microbiology·Z SalvadóE Barrio
Feb 22, 2011·Seminars in Cell & Developmental Biology·Sven J Saupe
Mar 12, 2011·Journal of Molecular Biology·Gary P NewnamYury O Chernoff
Mar 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ryan P McGlincheyReed B Wickner
Mar 23, 2011·Cold Spring Harbor Perspectives in Biology·David W Colby, Stanley B Prusiner
Oct 27, 2011·Annals of Neurology·Mathias Jucker, Lary C Walker
Nov 5, 2011·Prion·Reed B WicknerAnton Gorkovskiy
Feb 18, 2012·Nature·Randal HalfmannSusan Lindquist
May 15, 2012·Journal of Structural Biology·Juliane WinklerAxel Mogk
Aug 8, 2012·The Journal of Cell Biology·Juliane WinklerAxel Mogk
Aug 11, 2012·Genetics·Susan W Liebman, Yury O Chernoff
Aug 11, 2012·The Journal of Biological Chemistry·Lary C Walker, Harry LeVine
Nov 21, 2012·PLoS Pathogens·Liming Li, Anthony S Kowal

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Citations

Nov 21, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Razvan C StanMaristela M de Camargo
Sep 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tatiana A ChernovaKeith D Wilkinson
Mar 2, 2019·Current Genetics·Julien MortierAbram Aertsen
Jul 28, 2020·International Journal of Molecular Sciences·Tatiana A ChernovaYury O Chernoff
Mar 29, 2020·BMC Biology·Giulio ChiesaAhmad S Khalil
Sep 9, 2020·Experimental Cell Research·Henry Patrick OamenFabrice Caudron
Apr 30, 2021·Journal of Molecular Cell Biology·Hazrat IsmailXuebiao Yao
Oct 4, 2018·Chemical Reviews·Corey J WilsonJennifer M Heemstra

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Methods Mentioned

BETA
ubiquitination
environmental stress
environmental stresses
2-hybrid

Software Mentioned

CLUSTALW

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