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Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

Frontiers in Molecular Neuroscience

Nov 1, 2019

Luke McAlaryNeil R. Cashman

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Abstract

The discovery that prion protein can misfold into a pathological conformation that encodes structural information capable of both propagation and inducing severe neuropathology has revolutionized our understanding of neurodegenerative disease. Many neurodegenerative diseases with a prot...read more

Mentioned in this Paper

Amyotrophic Lateral Sclerosis
Cell Culture Techniques
Cu-Zn Superoxide Dismutase
DNA-Binding Proteins
Genes
Motor Neurons
Nerve Degeneration
Prion Diseases
Structure
In Vivo Study
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Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

Frontiers in Molecular Neuroscience

Nov 1, 2019

Luke McAlaryNeil R. Cashman

PMID: 31736708

DOI: 10.3389/fnmol.2019.00262

Abstract

The discovery that prion protein can misfold into a pathological conformation that encodes structural information capable of both propagation and inducing severe neuropathology has revolutionized our understanding of neurodegenerative disease. Many neurodegenerative diseases with a prot...read more

Mentioned in this Paper

Amyotrophic Lateral Sclerosis
Cell Culture Techniques
Cu-Zn Superoxide Dismutase
DNA-Binding Proteins
Genes
19
1
1

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