Prion protein adsorption to soil in a competitive matrix is slow and reduced

Environmental Science & Technology
Samuel E SaundersShannon Bartelt-Hunt

Abstract

It is likely that the soil environment serves as a stable reservoir of infectious CWD and scrapie prions as well as a potential reservoir of BSE. Prion adsorption to soil could play an important role in prion mobility, proteolysis, and infectivity. We modified previously published methods to quantify adsorbed prions via direct detection and studied prion adsorption to soil and soil minerals as a function of time through 60 days. Prion-infected brain homogenate was used as a complex, relevant prion source. We determined that maximum PrP adsorption requires days or weeks, depending on the soil or mineral, and is 2-5 orders of magnitude lower than previous studies using purified PrP(Sc) or recPrP. Because PrP adsorption to soil is slow and reduced in tissue homogenate, the possibility of prion transport in soil environments cannot be excluded and requires further investigation. Our results indicate that binding to soil may protect prions from degradation, consistent with prions' longevity in the environment. Adsorption of PrP to sterilized soil did not differ significantly from adsorption to unsterilized soil, which suggests that active biological processes do not significantly affect prion adsorption or degradation in the soil en...Continue Reading

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Sep 20, 2008·Environmental Science & Technology·Samuel E SaundersShannon L Bartelt-Hunt
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Aug 28, 2009·Environmental Science & Technology·Samuel E SaundersShannon L Bartelt-Hunt

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Citations

May 11, 2010·Environmental Science & Technology·Samuel E SaundersShannon L Bartelt-Hunt
May 17, 2011·Applied and Environmental Microbiology·Samuel E SaundersShannon L Bartelt-Hunt
Mar 25, 2011·Journal of Virology·Samuel E SaundersJason C Bartz
Jan 14, 2011·Journal of Virology·Michael B Miller, Surachai Supattapone
Sep 1, 2012·PloS One·Samuel E SaundersJason C Bartz
Jun 18, 2014·PloS One·Gabriele GiachinGiuseppe Legname
Feb 15, 2013·PLoS Pathogens·Shannon L Bartelt-Hunt, Jason C Bartz
Apr 28, 2011·Journal of Environmental Quality·Christen B SmithJoel A Pedersen
Jan 24, 2012·Chemosphere·Samuel E SaundersShannon L Bartelt-Hunt
Jun 2, 2017·Microbiology and Molecular Biology Reviews : MMBR·Mark Zabel, Aimee Ortega
Nov 30, 2018·PLoS Pathogens·Alsu KuznetsovaJudd M Aiken
Oct 11, 2019·MSphere·Sara A M HolecJason C Bartz
Apr 27, 2021·Acta Neuropathologica·Jason C Bartz
Apr 25, 2013·Environmental Science & Technology·Kurt H JacobsonJoel A Pedersen

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