Prions adhere to soil minerals and remain infectious.

PLoS Pathogens
Christopher J JohnsonJoel A Pedersen

Abstract

An unidentified environmental reservoir of infectivity contributes to the natural transmission of prion diseases (transmissible spongiform encephalopathies [TSEs]) in sheep, deer, and elk. Prion infectivity may enter soil environments via shedding from diseased animals and decomposition of infected carcasses. Burial of TSE-infected cattle, sheep, and deer as a means of disposal has resulted in unintentional introduction of prions into subsurface environments. We examined the potential for soil to serve as a TSE reservoir by studying the interaction of the disease-associated prion protein (PrP(Sc)) with common soil minerals. In this study, we demonstrated substantial PrP(Sc) adsorption to two clay minerals, quartz, and four whole soil samples. We quantified the PrP(Sc)-binding capacities of each mineral. Furthermore, we observed that PrP(Sc) desorbed from montmorillonite clay was cleaved at an N-terminal site and the interaction between PrP(Sc) and Mte was strong, making desorption of the protein difficult. Despite cleavage and avid binding, PrP(Sc) bound to Mte remained infectious. Results from our study suggest that PrP(Sc) released into soil environments may be preserved in a bioavailable form, perpetuating prion disease epiz...Continue Reading

References

May 1, 1976·Canadian Journal of Microbiology·H W Morgan, C T Corke
Feb 1, 1992·The Journal of General Virology·R A Bessen, R F Marsh
Feb 2, 1991·Lancet·P Brown, D C Gajdusek
Apr 1, 1985·Cell·B OeschL E Hood
Nov 1, 1987·Archives of Biochemistry and Biophysics·D C BoltonA Potempska
Feb 1, 1985·Journal of Virology·D C BoltonS B Prusiner
Nov 1, 1982·The Journal of Infectious Diseases·W J HadlowR E Race
May 2, 1996·Nature·J P FerrisL E Orgel
Jun 21, 1996·The Science of the Total Environment·G F Fries
Sep 1, 1996·Revue Scientifique Et Technique·L J Hoinville
Jun 27, 1998·Lancet·P Brown
Sep 25, 1998·The Journal of Biological Chemistry·D McKenzieJ Aiken
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·S B Prusiner
Dec 3, 1998·Revue neurologique·D Dormont
Jan 6, 2000·Lancet·K PostH Mehlhorn
May 24, 2000·Journal of Neurovirology·R I CarpH M Wisniewski
Apr 11, 2001·Trends in Biochemical Sciences·B Caughey
Jun 13, 2002·Scandinavian Journal of Gastroenterology·T C MartinsenH L Waldum
Nov 9, 2002·The Journal of Infectious Diseases·C WeissmannE Flechsig
Sep 5, 2003·Nature·Michael W Miller, Elizabeth S Williams
Sep 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·P-C KlöhnC Weissmann
Jun 23, 2004·Emerging Infectious Diseases·Michael W MillerLisa L Wolfe
Mar 12, 2005·Annual Review of Public Health·Ermias D Belay, Lawrence B Schonberger
Sep 9, 2005·Nature·Jay R SilveiraByron Caughey
Oct 15, 2005·Science·Harald SeegerAdriano Aguzzi

❮ Previous
Next ❯

Citations

Jun 18, 2014·PloS One·Gabriele GiachinGiuseppe Legname
Sep 17, 2013·Journal of Theoretical Biology·Tamer OrabyFrithjof Lutscher
Apr 9, 2014·Environmental Geochemistry and Health·Michael J LavelleKurt C VerCauteren
Feb 16, 2007·Journal of Virology·Anthony E Kincaid, Jason C Bartz
Oct 25, 2007·PloS One·Sacha GenovesiAlessandro Bertoli
May 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Beiru ZhangKeiichi Higuchi
Jun 25, 2008·Acta Veterinaria Scandinavica·Kristín B GudmundsdóttirTorkell Jóhannesson
Aug 14, 2008·PloS One·Cathrin E BruederleJohn Mark Carter
Aug 30, 2008·Environmental Science & Technology·Glen T HinckleyJoel A Pedersen
Sep 2, 2008·Emerging Infectious Diseases·Luisa GregoriRobert G Rohwer
Jan 23, 2009·Journal of Virology·Cristiano CoronaCristina Casalone
Apr 17, 2009·Environmental Science & Technology·Kurt H JacobsonJoel A Pedersen
Aug 28, 2009·Environmental Science & Technology·Samuel E SaundersShannon L Bartelt-Hunt
Sep 14, 2010·Journal of Environmental Quality·Kurt H JacobsonJoel A Pedersen
Nov 19, 2010·Journal of Virology·Nathaniel D DenkersEdward A Hoover
Feb 18, 2011·Nature Communications·W David WalterMichael W Miller
Mar 25, 2011·Journal of Virology·Samuel E SaundersJason C Bartz
Apr 28, 2011·Journal of Environmental Quality·Christen B SmithJoel A Pedersen
Jun 10, 2011·PloS One·Zaira E Arellano-AnayaDidier Vilette
Nov 3, 2011·Virology Journal·Muhammad Imran, Saqib Mahmood
Jun 21, 2012·Journal of the American Society for Mass Spectrometry·Robert SturmLingjun Li
Feb 15, 2013·PLoS Pathogens·Shannon L Bartelt-Hunt, Jason C Bartz
Jan 30, 2008·Archives of Virology·Gudmundur GeorgssonStefania Thorgeirsdottir
Dec 6, 2008·Molecular Biotechnology·Helen C ReesKevin C Gough
Aug 19, 2008·FEBS Letters·Dennisse Gonzalez-RomeroClaudio Soto
Jan 10, 2016·Anaerobe·Mohd MuzafarElizabeth M H Wellington
Aug 20, 2009·Ecological Applications : a Publication of the Ecological Society of America·Erik E OsnasMichael D Samuel
Jan 16, 2014·Journal of Neuropathology and Experimental Neurology·Frank O Bastian
Jan 24, 2012·Chemosphere·Samuel E SaundersShannon L Bartelt-Hunt
May 20, 2015·Cell Reports·Sandra PritzkowClaudio Soto
Dec 30, 2015·Cellular and Molecular Life Sciences : CMLS·Reed B Wickner, Amy C Kelly
Jun 24, 2010·Biochemical and Biophysical Research Communications·Kazunari NagaokaShirou Mohri
Jan 26, 2010·Journal of Autoimmunity·Jonathan J PowellLaetitia C Pele

❮ Previous
Next ❯

Datasets Mentioned

BETA
M14054

Methods Mentioned

BETA
infrared spectroscopy
X-ray
deamination
infrared photoacoustic spectroscopy

Related Concepts

Related Feeds

Bovine Spongiform Encephalopathy

Bovine spongiform encephalopathy is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. Here is the latest research.

Bovine Spongiform Encephalopathy (MDS)

Bovine spongiform encephalopathy is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. Here is the latest research.

© 2022 Meta ULC. All rights reserved