Prions are a common mechanism for phenotypic inheritance in wild yeasts.

Nature
Randal HalfmannSusan Lindquist

Abstract

The self-templating conformations of yeast prion proteins act as epigenetic elements of inheritance. Yeast prions might provide a mechanism for generating heritable phenotypic diversity that promotes survival in fluctuating environments and the evolution of new traits. However, this hypothesis is highly controversial. Prions that create new traits have not been found in wild strains, leading to the perception that they are rare 'diseases' of laboratory cultivation. Here we biochemically test approximately 700 wild strains of Saccharomyces for [PSI(+)] or [MOT3(+)], and find these prions in many. They conferred diverse phenotypes that were frequently beneficial under selective conditions. Simple meiotic re-assortment of the variation harboured within a strain readily fixed one such trait, making it robust and prion-independent. Finally, we genetically screened for unknown prion elements. Fully one-third of wild strains harboured them. These, too, created diverse, often beneficial phenotypes. Thus, prions broadly govern heritable traits in nature, in a manner that could profoundly expand adaptive opportunities.

References

Mar 25, 1992·Nucleic Acids Research·D GietzR H Schiestl
Jan 16, 1999·Molecular and Cellular Biology·G P NewnamY O Chernoff
Mar 11, 2000·Molecular Cell·N Sondheimer, S Lindquist
Feb 26, 2000·Molecular Microbiology·Y O ChernoffS M Belenkiy
Nov 14, 2002·Cell Cycle·Joanna Bloom, Michele Pagano
Nov 14, 2002·Cell Cycle·Steven B Haase, Steven I Reed
Aug 2, 2003·Molecular Microbiology·Catarina G ResendeMick F Tuite
Aug 28, 2003·Evolution; International Journal of Organic Evolution·Joanna Masel, Aviv Bergman
Sep 26, 2003·The Journal of Biological Chemistry·Dmitry S KryndushkinVitaly V Kushnirov
Jan 22, 2004·Bioinformatics·Emmanuel ParadisKorbinian Strimmer
Jun 11, 2004·Annual Review of Biochemistry·Peter ChienAngela H DePace
Feb 11, 2005·Eukaryotic Cell·Youtao SongDaniel C Masison
Jul 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Toru NakayashikiReed B Wickner
May 19, 2007·FEBS Letters·Yury O Chernoff
Jul 17, 2007·Nature Reviews. Microbiology·Reed B WicknerToru Nakayashiki
Dec 11, 2008·Journal of Visualized Experiments : JoVE·Randal Halfmann, Susan Lindquist
Dec 11, 2008·PLoS Biology·Jens TyedmersSusan Lindquist
Feb 13, 2009·Nature·Gianni LitiEdward J Louis
May 20, 2009·Bioinformatics·Heng Li, Richard Durbin
Jun 3, 2009·Evolution; International Journal of Organic Evolution·Alex K Lancaster, Joanna Masel
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Nov 13, 2009·Biology Direct·Eugene V Koonin, Yuri I Wolf
Jan 15, 2010·Trends in Cell Biology·Randal HalfmannSusan Lindquist
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Andrew P Feinberg, Rafael A Irizarry
Feb 25, 2011·Seminars in Cell & Developmental Biology·Reed B WicknerAmy Kelly
Mar 15, 2011·Seminars in Cell & Developmental Biology·Emily T Crow, Liming Li
Mar 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ryan P McGlincheyReed B Wickner

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Citations

Mar 15, 2013·Trends in Cell Biology·Gregory A Newby, Susan Lindquist
Oct 8, 2013·Trends in Microbiology·Takao Kasuga, Mark Gijzen
Feb 19, 2013·Nature Reviews. Genetics·Ueli GrossniklausSusan Lindquist
Apr 5, 2012·Nature Structural & Molecular Biology·Rodrigo Diaz-Espinoza, Claudio Soto
Jun 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Alfons J M DebetsSven J Saupe
Jun 30, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rajaraman KrishnanSusan Lindquist
Aug 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Helen R SaibilAchilleas S Frangakis
Nov 14, 2012·The Journal of Biological Chemistry·David L LancasterRichard A Rachubinski
Nov 12, 2013·FEMS Yeast Research·Myriam CrapeauChristophe Cullin
Oct 10, 2012·Molecular and Cellular Biology·Denis A KiktevYury O Chernoff
Nov 28, 2013·Annual Review of Genetics·Stanley B Prusiner
Jun 27, 2012·Microbial Cell Factories·Alba EspargaróSalvador Ventura
Mar 1, 2012·BMC Biology·Mark L Siegal, Joanna Masel
Aug 24, 2012·Biology Direct·Eugene V Koonin
Jan 10, 2013·PLoS Biology·Douglas M Fowler, Jeffery W Kelly
Feb 6, 2013·PLoS Genetics·David A Bateman, Reed B Wickner
May 30, 2013·PLoS Genetics·Ian R Adams, Richard R Meehan
Jul 5, 2013·PLoS Genetics·Alasdair J E GordonChristophe Herman
Sep 17, 2013·PLoS Genetics·Gal Hagit RomanoMartin Kupiec
Jan 1, 2014·PloS One·Cristian Del FabbroFederico M Giorgi
Jun 2, 2012·PLoS Pathogens·Sven J Saupe, Asen Daskalov
Nov 21, 2012·PLoS Pathogens·Liming Li, Anthony S Kowal
Apr 5, 2013·PLoS Pathogens·Silvia CaloJoseph Heitman
Aug 11, 2012·Genetics·Susan W Liebman, Yury O Chernoff
Sep 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Amy C KellyReed B Wickner
Oct 5, 2013·The Journal of Chemical Physics·Joseph FoleyMartin Muschol
Jan 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Babak JavidEric J Rubin
Apr 9, 2014·Journal of Biochemistry·Shinju Sugiyama, Motomasa Tanaka
May 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Matthew D EdwardsGerald R Fink
Oct 13, 2012·Annual Review of Cell and Developmental Biology·Jeremy D O'ConnellEdward M Marcotte
Jul 12, 2014·Nucleic Acids Research·Gary LoughranJohn F Atkins
Nov 19, 2014·Proceedings of the National Academy of Sciences of the United States of America·Anna ReymerBengt Nordén
Sep 25, 2015·Proceedings of the National Academy of Sciences of the United States of America·Eric J HaydenAndreas Wagner
Feb 18, 2016·FEMS Yeast Research·Rike B StelkensDuncan Greig
Sep 26, 2015·Annual Review of Cell and Developmental Biology·Kausik Si
Dec 9, 2014·Prion·Anton A NizhnikovIrina L Derkatch
Mar 5, 2015·Prion·Meredith E Jackrel, James Shorter
Mar 5, 2015·Prion·Alvaro J AmorDale M Cameron
Sep 12, 2015·Annals of Botany·Ian M Ehrenreich, David W Pfennig
Jul 4, 2015·Nucleic Acids Research·Xuefeng ZhuClaes M Gustafsson

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