Prior and novel coronaviruses, Coronavirus Disease 2019 (COVID-19), and human reproduction: what is known?

Fertility and Sterility
James SegarsAmerican Society for Reproductive Medicine Coronavirus/COVID-19 Task Force


To summarize current understanding of the effects of novel and prior coronaviruses on human reproduction, specifically male and female gametes, and in pregnancy. Review of English publications in PubMed and Embase to April 6, 2020. Articles were screened for reports including coronavirus, reproduction, pathophysiology, and pregnancy. None. Reproductive outcomes, effects on gametes, pregnancy outcomes, and neonatal complications. Seventy-nine reports formed the basis of the review. Coronavirus binding to cells involves the S1 domain of the spike protein to receptors present in reproductive tissues, including angiotensin-converting enzyme-2 (ACE2), CD26, Ezrin, and cyclophilins. Severe Acute Respiratory Syndrome Coronavirus 1 (SARS-CoV-1) may cause severe orchitis leading to germ cell destruction in males. Reports indicate decreased sperm concentration and motility for 72-90 days following Coronavirus Disease 2019 (COVID-19) infection. Gonadotropin-dependent expression of ACE2 was found in human ovaries, but it is unclear whether SARS-Coronavirus 2 (CoV-2) adversely affects female gametogenesis. Evidence suggests that COVID-19 infection has a lower maternal case fatality rate than SARS or Middle East respiratory syndrome (MERS), ...Continue Reading

Associated Clinical Trials


Jun 11, 2020·Journal of Medical Virology·Anis AbobakerAboubaker Alzwi
Aug 20, 2020·The World Journal of Men's Health·Mohammad Ali KhaliliAshok Agarwal
Sep 17, 2020·International Journal of Environmental Research and Public Health·Francesca GoriniGiorgio Iervasi
Aug 21, 2020·Geburtshilfe und Frauenheilkunde·Philipp KlaritschUNKNOWN board of the OEGGG
Jul 1, 2020·Andrology·Liqiang GuoMingzhen Yuan
Nov 23, 2020·Maternal and Child Health Journal·Xue Ling AngJill Cheng Sim Lee
Jan 9, 2021·Reproductive Sciences·Ramya SethuramHusam M Abu-Soud
Nov 30, 2020·Journal of Reproductive Immunology·Marcelo Borges CavalcanteJoanne Kwak-Kim
Jan 30, 2021·Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia·Bruno Ramalho de CarvalhoAlessandra Cristina Marcolin
Feb 3, 2021·Journal of Developmental Origins of Health and Disease·Claudia RiedelMa Cecilia Opazo
Oct 29, 2020·BMC Oral Health·Sausan Al KawasA B Rani Samsudin
Dec 19, 2020·International Journal of Environmental Research and Public Health·Shubhadeep RoychoudhuryPetr Slama
Feb 2, 2021·Frontiers in Public Health·Om Prakash MehtaNguyen Tien Huy
Nov 26, 2020·Emergent Materials·Ayca AydinCem Bulent Ustundag
Jan 16, 2021·International Journal of Environmental Research and Public Health·Michail PapapanouCharalampos Siristatidis
Feb 16, 2021·Emergent Materials·Ayca AydinCem Bulent Ustundag
Feb 28, 2021·Environmental Science and Pollution Research International·Mrunmayee Manjari Sahoo
Feb 2, 2021·Saudi Journal of Biological Sciences·Nesrein M HashemAyman A Swelum
Mar 18, 2021·Hormones : International Journal of Endocrinology and Metabolism·Alev SelekŞinasi Erol Bolu
Jun 13, 2020·The Science of the Total Environment·Muhammad Mazhar IqbalMuhammad Jawed Iqbal
May 6, 2021·Amino Acids·Pawan Kumar RaghavDinesh Kumar
May 13, 2021·Journal of Assisted Reproduction and Genetics·Mojgan MoshrefiMohammad Ali Khalili
May 29, 2021·Wiener klinische Wochenschrift·Paulo Roberto Carneiro GomesDaniel Fernando Pereira Vasconcelos
Jul 1, 2021·Global Reproductive Health·Anne E Martini
Jun 29, 2021·Middle East Fertility Society Journal·Koushik BhattacharyaAlak Kumar Syamal
Jul 8, 2021·Journal of Molecular Histology·Arash Ardestani Zadeh, Davood Arab
Aug 6, 2021·Clinical and Experimental Reproductive Medicine·Hamidreza MoslehRonak Shabani
Aug 19, 2021·American Journal of Reproductive Immunology : AJRI·Arad DotanYehuda Shoenfeld

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