Prior antibiotic exposure and risk of type 2 diabetes among Veterans

Primary Care Diabetes
P Jordan DavisMark D Schwartz

Abstract

Exposure to antibiotics may increase the risk of type 2 diabetes. Veterans are at increased risk for diabetes and for exposure to antibiotics. To determine the impact of antibiotic exposure for risk of diabetes. Retrospective cohort study. Veterans at the New York Harbor Healthcare System enrolled in primary care, 2004-2014, with ≥2 glycosylated hemoglobin test results <6.5%. The primary exposure was any antimicrobial prescribed >6 months prior to the date of diabetes diagnosis, loss to follow-up, death, or the end of the study, measured as the number of courses of antimicrobial prescriptions filled and the mean daily dose (MDD). The primary outcome was incident diagnosis of diabetes through 2014, defined ≥2 ICD-9 codes for diabetes or ≥2 prescriptions of diabetes medications, other than metformin. Cox proportional hazards regression was used to model antimicrobial medications, demographic and anthropometric measures, and comorbid cardiovascular conditions to incident diabetes. Models incorporated time varying covariates of antimicrobial medication and MDD to analyze associations by antimicrobial class. Among 14,361 Veterans, 9922 (69.1%) were prescribed any antimicrobial medication during the study period. 1413 (9.8%) individu...Continue Reading

Citations

Sep 8, 2020·International Journal of Epidemiology·Jinqiu YuanMichael Moore
Jan 8, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Martin J BlaserMark Nichter
Oct 9, 2021·Environmental Science and Pollution Research International·Jielin ZhouKeyang Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Madhur NayanCanadian Drug Safety and Effectiveness Research Network (CDSERN)
Primary Health Care Research & Development
Lauren A BarnettDanielle A van der Windt
© 2022 Meta ULC. All rights reserved