Prior appendectomy and the phenotype and course of Crohn's disease

World Journal of Gastroenterology : WJG
Jacques CosnesJean-Pierre Gendre

Abstract

To determine whether prior appendectomy modifies the phenotype and severity of Crohn's disease. Appendectomy status and smoking habits were specified by direct interview in 2838 patients consecutively seen between 1995 and 2004. Occurrence of complications and therapeutic needs were reviewed retrospectively. Additionally, annual disease activity was assessed prospectively between 1995 and 2004 in patients who had not had ileocecal resection and of a matched control group. Compared to 1770 non-appendectomized patients, appendectomized patients more than 5 years before Crohn's disease diagnosis (n=716) were more often females, smokers, with ileal disease. Cox regression showed that prior appendectomy was positively related to the risk of intestinal stricture (adjusted hazard ratio, 1.24; 95% confidence interval, 1.13 to 1.36; P=0.02) and inversely related to the risk of perianal fistulization (adjusted hazard ratio, 0.75; 95% confidence interval, 0.68 to 0.83; P=0.002). No difference was observed between the two groups regarding the therapeutic needs, except for an increased risk of surgery in appendectomized patients, attributable to the increased prevalence of ileal disease. Between 1995 and 2004, Crohn's disease was active dur...Continue Reading

References

Sep 1, 1991·Scandinavian Journal of Gastroenterology·A WettergrenV Binder
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·J E Lennard-Jones
Apr 2, 1988·British Medical Journal·D J BarkerM E Wadsworth
Feb 1, 1994·International Journal of Epidemiology·P Primatesta, M J Goldacre
Feb 1, 1996·Gastroenterology·J CosnesJ P Gendre
Feb 1, 1997·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·G AhlbergB Frenckner
Apr 22, 1999·Diseases of the Colon and Rectum·I E KoutroubakisO N Manousos
Apr 5, 2000·Journal of Pediatric Gastroenterology and Nutrition·E LindbergH Hildebrand
Oct 2, 2001·The British Journal of Surgery·R E Andersson
Jan 5, 2002·American Journal of Surgery·I Prieto-NietoL Garcia-Sancho-Martin
Jan 29, 2002·The American Journal of Gastroenterology·L CasertaG Riegler
Feb 13, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·B SiciliaF Gomollón
Apr 17, 2002·Virchows Archiv : an International Journal of Pathology·Petra C StanglGeorg Oberhuber
May 2, 2002·European Journal of Gastroenterology & Hepatology·Mark A FeeneyJonathon A Snook
Jul 20, 2002·Inflammatory Bowel Diseases·Jacques CosnesJean-Pierre Gendre
Jan 4, 2003·Gastroenterology·Roland E AnderssonAnders Ekbom
Dec 11, 2003·Digestive Surgery·Bobby TingstedtRoland Andersson
May 26, 2004·Best Practice & Research. Clinical Gastroenterology·Jacques Cosnes
Dec 2, 2004·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·O N TuckerF B V Keane
Apr 6, 2005·Seminars in Diagnostic Pathology·Mary P Bronner
May 10, 2005·European Journal of Gastroenterology & Hepatology·Gabriele RieglerRomano Carratù

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Citations

Sep 9, 2008·The American Journal of Gastroenterology·Gilaad G KaplanJoshua Korzenik
Apr 30, 2016·European Journal of Gastroenterology & Hepatology·Vivek ChhayaRichard C Pollok
Dec 13, 2006·The American Journal of Gastroenterology·John P BurkeP Ronan O'Connell
Mar 4, 2015·Nature Reviews. Gastroenterology & Hepatology·Ashwin N Ananthakrishnan
Jan 27, 2016·World Journal of Gastroenterology : WJG·Elisa LiveraniAndrea Belluzzi
Aug 26, 2020·Journal of Gastroenterology and Hepatology·Kimberley W J van der SlootGerard Dijkstra
Aug 10, 2019·Gastroenterology Research and Practice·Dafan ChenXinjian Wan
Dec 23, 2020·Expert Review of Gastroenterology & Hepatology·Ming-Yang SongBing-Rong Liu
Feb 2, 2021·Surgical Infections·Abdurakhmon T BabakhanovTimur M Saliev
Feb 2, 2010·Gastroentérologie Clinique Et Biologique·F CarbonnelJ Cosnes

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