Prior Balloon Valvuloplasty Versus Direct Transcatheter Aortic Valve Replacement: Results From the DIRECTAVI Trial

JACC. Cardiovascular Interventions
Florence LeclercqGuillaume Cayla

Abstract

The aim of this study was to evaluate device success of transcatheter aortic valve replacement (TAVR) using new-generation balloon-expandable prostheses with or without balloon aortic valvuloplasty (BAV). Randomized studies are lacking comparing TAVR without BAV against the conventional technique of TAVR with BAV. DIRECTAVI (Direct Transcatheter Aortic Valve Implantation) was an open-label noninferiority study that randomized patients undergoing TAVR using the Edwards SAPIEN 3 valve with or without prior balloon valvuloplasty. The primary endpoint was the device success rate according to Valve Academic Research Consortium-2 criteria, which was evaluated using a 7% noninferiority margin. The secondary endpoint included procedural and 30-day adverse events. Device success was recorded for 184 of 236 included patients (78.0%). The rate of device success in the direct implantation group (n = 97 [80.2%]) was noninferior to that in the BAV group (n = 87 [75.7%]) (mean difference 4.5%; 95% confidence interval: -4.4% to 13.4%; p = 0.02 for noninferiority). No severe prosthesis-patient mismatch or severe aortic regurgitation occurred in any group. In the direct implantation group, 7 patients (5.8%) required BAV to cross the valve. Adver...Continue Reading

References

Apr 5, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Stefan SackRaimund Erbel
Jul 23, 2011·JACC. Cardiovascular Interventions·Eberhard GrubeLutz Buellesfeld
Jul 23, 2011·JACC. Cardiovascular Interventions·Alec Vahanian, Dominique Himbert
Apr 21, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Pak Hei ChanNeil Moat
Jul 28, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Claude Du CailarBernard Albat
Apr 22, 2014·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Claudia FiorinaFederica Ettori
Aug 2, 2014·Clinical Cardiology·Helge MöllmannChristian Hamm
Mar 23, 2017·Journal of Interventional Cardiology·Nelson Wang, Sean Lal
Apr 14, 2017·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Vincent AuffretJosep Rodés-Cabau
Sep 28, 2018·Journal of the American College of Cardiology·Howard C HerrmannAndrzej S Kosinski
Mar 14, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Christian ButterTanja K Rudolph
Apr 1, 2019·JACC. Cardiovascular Interventions·Konstantinos ToutouzasDimitris Tousoulis

❮ Previous
Next ❯

Citations

Jul 24, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Antonio MangieriAntonio Colombo
Nov 13, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Georgios BenetosKonstantinos Toutouzas
Mar 7, 2020·JACC. Cardiovascular Interventions·Eberhard Grube, Jan-Malte Sinning
Oct 3, 2020·Hellenic Journal of Cardiology : HJC = Hellēnikē Kardiologikē Epitheōrēsē·Christos EftychiouPanayiotis Avraamides
Jun 19, 2021·Circulation. Cardiovascular Interventions·Julien TernacleMichael J Mack

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cardiovascular Revascularization Medicine : Including Molecular Interventions
Seyed Hossein Aalaei-AndabiliR David Anderson
Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Carlos FerreraCarlos Macaya
The Journal of Thoracic and Cardiovascular Surgery
Mani ArsalanThomas Walther
© 2021 Meta ULC. All rights reserved