Prior events predict cerebrovascular and coronary outcomes in the PROGRESS trial

Stroke; a Journal of Cerebral Circulation
Hisatomi ArimaPROGRESS Collaborative Group

Abstract

The relationship between baseline and recurrent vascular events may be important in the targeting of secondary prevention strategies. We examined the relationship between initial event and various types of further vascular outcomes and associated effects of blood pressure (BP)-lowering. Subsidiary analyses of the Perindopril Protection Against Recurrent Stroke Study (PROGRESS) trial, a randomized, placebo-controlled trial that established the benefits of BP-lowering in 6105 patients (mean age 64 years, 30% female) with cerebrovascular disease, randomly assigned to either active treatment (perindopril for all, plus indapamide in those with neither an indication for, nor a contraindication to, a diuretic) or placebo(s). Stroke subtypes and coronary events were associated with 1.5- to 6.6-fold greater risk of recurrence of the same event (hazard ratios, 1.51 to 6.64; P=0.1 for large artery infarction, P<0.0001 for other events). However, 46% to 92% of further vascular outcomes were not of the same type. Active treatment produced comparable reductions in the risk of vascular outcomes among patients with a broad range of vascular events at entry (relative risk reduction, 25%; P<0.0001 for ischemic stroke; 42%, P=0.0006 for hemorrhag...Continue Reading

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Citations

May 31, 2011·International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care·Qun LiuMinhui Qian
Jul 5, 2012·Age·Petra G van PeetWouter de Ruijter
Jan 22, 2009·Journal of Hypertension·Kei AsayamaUNKNOWN Japan Arteriosclerosis Longitudinal Study (JALS) group
Mar 1, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Norihiro SuzukiYasushi Okada
Apr 28, 2009·Medicina clínica·Carmen SuárezUNKNOWN en representación de los investigadores del registro REACH España
Jul 1, 2008·Journal of the American Society of Hypertension : JASH·Bryan Williams
Sep 8, 2011·The Journal of Clinical Hypertension·Hisatomi Arima, John Chalmers
Feb 24, 2009·Archives of Cardiovascular Diseases·Jean-Michel TartièreChristophe Tribouilloy
Aug 22, 2013·Journal of the American Heart Association·Anna De SimoniAnn Louise Kinmonth
May 9, 2013·Circulation. Cardiovascular Quality and Outcomes·Nilay S ShahDonald M Lloyd-Jones
Jan 30, 2010·Stroke; a Journal of Cerebral Circulation·Pierre AmarencoUNKNOWN Stroke Prevention by Aggressive Reduction in Cholesterol Levels Investigators
Feb 27, 2019·Critical Care Nursing Quarterly·Edward T Van MatreKeaton S Smetana
Jun 7, 2019·Topics in Stroke Rehabilitation·Emily A KringleElizabeth R Skidmore
Mar 3, 2020·Stroke; a Journal of Cerebral Circulation·Anette Riisgaard RibeMorten Fenger-Grøn
Jun 20, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Gargi BanerjeeUNKNOWN CROMIS-2 collaborators
Apr 4, 2017·Clinical Medicine : Journal of the Royal College of Physicians of London·Zhe Kang LawNikola Sprigg
May 1, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Naoyuki TakashimaUNKNOWN Shiga Stroke and Heart Attack Registry Group
Oct 23, 2020·Journal of Applied Physiology·Allison S HyngstromMatthew J Durand
Apr 28, 2021·Stroke; a Journal of Cerebral Circulation·Giorgio B BoncoraglioIrene Tramacere

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