Prior exercise and the response to insulin-induced hypoglycemia in the dog

American Journal of Physiology. Endocrinology and Metabolism
Y KoyamaD Wasserman

Abstract

To test whether hepatic insulin action and the response to an insulin-induced decrement in blood glucose are enhanced in the immediate postexercise state as they are during exercise, dogs had sampling (artery, portal vein, and hepatic vein) catheters and flow probes (portal vein and hepatic artery) implanted 16 days before a study. After 150 min of moderate treadmill exercise or rest, dogs were studied during a 150-min hyperinsulinemic (1 mU.kg(-1).min(-1)) euglycemic (n = 5 exercised and n = 9 sedentary) or hypoglycemic (65 mg/dl; n = 8 exercised and n = 9 sedentary) clamp. Net hepatic glucose output (NHGO) and endogenous glucose appearance (R(a)) and utilization (R(d)) were assessed with arteriovenous and isotopic ([3-(3)H]glucose) methods. Results show that, immediately after prolonged, moderate exercise, in relation to sedentary controls: 1) the glucose infusion rate required to maintain euglycemia, but not hypoglycemia, was higher; 2) R(d) was greater under euglycemic, but not hypoglycemic conditions; 3) NHGO, but not R(a), was suppressed more by a hyperinsulinemic euglycemic clamp, suggesting that hepatic glucose uptake was increased; 4) a decrement in glucose completely reversed the enhanced suppression of NHGO by insuli...Continue Reading

References

Jan 1, 1978·Ultrasound in Medicine & Biology·C J HartleyJ S Cole
Dec 1, 1991·The American Journal of Physiology·P De FeoG B Bolli
Jan 1, 1991·The American Journal of Physiology·D H WassermanN N Abumrad
Oct 1, 1987·The American Journal of Physiology·H WahrenbergP Arner
Mar 1, 1988·The American Journal of Physiology·K J MikinesH Galbo
Apr 1, 1988·The American Journal of Physiology·D H WassermanA D Cherrington
Nov 1, 1983·The Journal of Clinical Investigation·C BogardusS Azhar
Sep 1, 1994·The American Journal of Physiology·C M BergerD H Wasserman
Aug 1, 1994·Diabetes Care·D H Wasserman, B Zinman
Aug 1, 1993·Journal of Applied Physiology·D H WassermanD P Bracy
Aug 1, 1996·The Journal of Clinical Investigation·S N DavisR Mosqueda-Garcia
Apr 1, 1997·The American Journal of Physiology·B A ZinkerD H Wasserman
Jan 24, 1998·Metabolism: Clinical and Experimental·M MatsuhisaY Yamasaki
Jun 11, 1999·The American Journal of Physiology·P GalassettiD H Wasserman
Dec 22, 1999·The American Journal of Physiology·P GalassettiD H Wasserman

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Citations

Jul 9, 2014·Molecular and Cellular Endocrinology·Malihe AvesehSaeed Esmaeili-Mahani
Nov 23, 2005·Pediatric Clinics of North America·Christopher RyanDorothy Becker
Dec 2, 2004·Sports Medicine·Christos S Katsanos
Jan 5, 2018·The Journal of Clinical Endocrinology and Metabolism·Jane NaufahuRichard W A Mackenzie
Apr 13, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Gérald SeematterLuc Tappy
Mar 29, 2008·Metabolic Syndrome and Related Disorders·G SeematterL Tappy
Sep 1, 2005·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·R Richard PencekDavid H Wasserman
Feb 2, 2006·American Journal of Physiology. Endocrinology and Metabolism·Darleen A SandovalStephen N Davis
Jan 18, 2003·American Journal of Physiology. Endocrinology and Metabolism·Tony K T LamAdria Giacca
Oct 31, 2020·Journal of Veterinary Internal Medicine·Francesca Del BaldoFederico Fracassi

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