Prior hypothermia attenuates malignant hyperthermia in susceptible swine

Anesthesia and Analgesia
P A IaizzoK G Belani

Abstract

This study was designed to determine the extent by which mild or moderate hyperthermia attenuates the triggering of malignant hypothermia (MH) induced by the combined administration of halothane and succinylcholine. Sixteen susceptible swine were initially anesthetized with nontriggering drugs and then either kept normothermic (approximately equal to 38 degrees C, n = 6) or cooled to induce mild (approximately equal to 35 degrees C, n = 6), or moderate (approximately equal to 33 degrees C, n = 4) hypothermia. Next, after a 30-min control period, the normothermic and mildly hypothermic animals were administered 1 minimum alveolar anesthetic concentration (MAC) halothane followed by a bolus dose of succinylcholine (2 mg/kg). Within 10 min all normothermic animals developed fulminant MH, whereas the onset of MH was slowed or was absent in the mildly hypothermic group. To test whether moderate hypothermia could more effectively minimize the signs of a MH episode, this group of animals was exposed to 1.5 MAC halothane followed 10 min later by a 3-mg/kg bolus of succinylcholine. MH was not induced and anesthesia was then changed to nontriggering drugs (ketamine and pancuronium). The animals were then aggressively rewarmed to 38 degre...Continue Reading

References

Nov 1, 1991·Investigative Radiology·P A Iaizzo, R J Palahniuk
Mar 1, 1991·Anesthesiology·D J WedelJ H Milde
Jul 1, 1985·Anesthesia and Analgesia·H Ording
Jul 1, 1970·Canadian Anaesthetists' Society Journal·B A Britt, W Kalow
Mar 1, 1995·Mayo Clinic Proceedings·D J WedelP A Iaizzo
Jul 1, 1994·Anesthesia and Analgesia·P A Iaizzo, D J Wedel

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Citations

Dec 1, 2002·Journal of Clinical Neuromuscular Disease·Josef Finsterer
Dec 3, 1998·Acta Anaesthesiologica Scandinavica·M ImamuraT Kumazawa
Nov 12, 2014·Der Anaesthesist·T MetterleinM Anetseder
Dec 10, 2003·Best Practice & Research. Clinical Anaesthesiology·Kate Leslie, Daniel I Sessler
Mar 23, 2006·Archives of Disease in Childhood·A S El-Radhi, W Barry
Mar 23, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Jonathan D LeffHenry Rosenberg
Mar 8, 2011·The Journal of Thoracic and Cardiovascular Surgery·Thomas MetterleinPeter Kranke
Nov 22, 2005·Journal of Clinical Anesthesia·Annette SchmidtRainer Kentner
Apr 9, 2011·Anesthesia and Analgesia·Thomas MetterleinMartin Anetseder
Jun 12, 1997·The New England Journal of Medicine·D I Sessler
Oct 16, 1999·Anesthesiology·G FroebaM Georgieff

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