Prior infection of pigs with swine influenza viruses is a barrier to infection with avian influenza viruses

Veterinary Microbiology
Annebel De Vleeschauwer, Kristien Van Reeth

Abstract

Although pigs are susceptible to avian influenza viruses (AIV) of different subtypes, the incidence of AIV infections in the field appears to be low. Swine H1N1, H3N2 and H1N2 influenza viruses (SIV) are enzootic worldwide and most pigs have antibodies to 1 or more SIV subtypes. This study aimed to examine whether infection-immunity to H1N1 or H3N2 SIV may (1) protect pigs against subsequent infections with AIV of various haemagglutinin and/or neuraminidase subtypes and/or (2) interfere with the serological diagnosis of AIV infection by haemagglutination inhibition (HI) or virus neutralization (VN) tests. Pigs were inoculated intranasally with an H1N1 or H3N2 SIV or left uninoculated. Four or 6 weeks later all pigs were challenged intranasally with 1 of 3 AIV subtypes (H4N6, H5N2 or H7N1). Fifteen out of 17 challenge control pigs shed the respective AIV for 4-6 days post-inoculation and 16 developed HI and VN antibodies. In contrast, 28 of the 29 SIV-immune pigs did not have detectable AIV shedding. Only 12 SIV-immune pigs developed HI antibodies to the AIV used for challenge and 14 had VN antibodies. Antibody titres to the AIV were low in both control and SIV-immune pigs. Our data show that prior infection of pigs with SIV is ...Continue Reading

References

Sep 1, 1994·The Journal of General Virology·H KidaR G Webster
Oct 28, 2004·Veterinary Immunology and Immunopathology·Steven Van GuchtKristien Van Reeth
Apr 11, 2008·Virus Genes·Yan-Long CongJin-Hua Liu
Jul 12, 2008·PLoS Pathogens·Aleksandr S LipatovDavid E Swayne
Apr 11, 2009·Journal of Virology·Jun Han LeeYoung Ki Choi
May 21, 2009·Influenza and Other Respiratory Viruses·Kristien Van ReethGuus Koch
Aug 18, 2009·PloS One·Annebel De VleeschauwerKristien Van Reeth

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Citations

May 22, 2013·Veterinary Immunology and Immunopathology·Tufária MussáMaría Montoya
Mar 26, 2013·Molecular Immunology·Elisa CrisciMaria Montoya
Aug 12, 2016·Journal of Virology·Stephanie C TalkerWilhelm Gerner
Jul 25, 2015·Epidemiology and Infection·W D TannerA V Gundlapalli
May 20, 2011·BMC Infectious Diseases·Kristian ThorlundLehana Thabane
Sep 26, 2012·Expert Review of Vaccines·Michael SchotsaertGeert Leroux-Roels
Jan 1, 2010·Viruses·Nicole M Bouvier, Anice C Lowen
Sep 8, 2015·Vaccines·Matthew R SandbulteJames A Roth

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