Prior information for population pharmacokinetic and pharmacokinetic/pharmacodynamic analysis: overview and guidance with a focus on the NONMEM PRIOR subroutine.

Journal of Pharmacokinetics and Pharmacodynamics
Anna H-X P Chan KwongSonia Khier

Abstract

Population pharmacokinetic analysis is used to estimate pharmacokinetic parameters and their variability from concentration data. Due to data sparseness issues, available datasets often do not allow the estimation of all parameters of the suitable model. The PRIOR subroutine in NONMEM supports the estimation of some or all parameters with values from previous models, as an alternative to fixing them or adding data to the dataset. From a literature review, the best practices were compiled to provide a practical guidance for the use of the PRIOR subroutine in NONMEM. Thirty-three articles reported the use of the PRIOR subroutine in NONMEM, mostly in special populations. This approach allowed fast, stable and satisfying modelling. The guidance provides general advice on how to select the most appropriate reference model when there are several previous models available, and to implement and weight the selected parameter values in the PRIOR function. On the model built with PRIOR, the similarity of estimates with the ones of the reference model and the sensitivity of the model to the PRIOR values should be checked. Covariates could be implemented a priori (from the reference model) or a posteriori, only on parameters estimated witho...Continue Reading

References

Jun 11, 2003·Journal of Pharmacokinetics and Pharmacodynamics·Per O GisleskogStuart L Beal
Sep 28, 2006·Journal of Pharmacokinetics and Pharmacodynamics·Smita A KshirsagarDavide Verotta
Mar 9, 2007·European Journal of Clinical Pharmacology·Grant LangdonMats Karlsson
Jul 9, 2008·Journal of Biopharmaceutical Statistics·Aristides Dokoumetzidis, Leon Aarons
Jan 29, 2010·Clinical Pharmacology and Therapeutics·M CellaO Della Pasqua
Jun 15, 2010·Plastic Surgical Nursing : Official Journal of the American Society of Plastic and Reconstructive Surgical Nurses·Candise Flippin
Jan 4, 2012·Cancer Chemotherapy and Pharmacology·Mikkel Krogh-MadsenPer Hartvig Honoré
Feb 4, 2012·British Journal of Clinical Pharmacology·Massimo CellaOscar Della Pasqua
Jan 12, 2013·Journal of Pharmacokinetics and Pharmacodynamics·Rocío Lledó-GarcíaMats O Karlsson
Jul 5, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Katrine Rørbæk KnøsgaardJohannes N van den Anker
Jul 23, 2016·British Journal of Clinical Pharmacology·Jonás Samuel Pérez-BlancoMaría José García
Dec 29, 2016·CPT: Pharmacometrics & Systems Pharmacology·B GuiastrennecM Bergstrand
Aug 2, 2017·Current Therapeutic Research, Clinical and Experimental·Asuka NemotoKazue Yamaoka
Sep 10, 2017·Journal of Pharmacokinetics and Pharmacodynamics·Anne-Gaëlle DosneMats O Karlsson
Jul 25, 2018·Antimicrobial Agents and Chemotherapy·Ali Mohamed AliUNKNOWN WWARN Amodiaquine PK Study Group
May 3, 2019·CPT: Pharmacometrics & Systems Pharmacology·Robert J Bauer
Dec 18, 2019·Antimicrobial Agents and Chemotherapy·Mahmoud Tareq AbdelwahabPaolo Denti

❮ Previous
Next ❯

Citations

Nov 15, 2020·European Journal of Clinical Pharmacology·Xueting YaoDongyang Liu
May 13, 2021·Archives of Disease in Childhood·Samira Samiee-ZafarghandyJohn Van Den Anker
Aug 11, 2021·Pharmaceutics·Aymara Sancho-AraizIñaki F Trocóniz
Aug 24, 2021·Antimicrobial Agents and Chemotherapy·Santosh WaghBernd Meibohm
Oct 28, 2021·British Journal of Clinical Pharmacology·Álvaro Corral AlaejosJonás Samuel Pérez-Blanco

❮ Previous
Next ❯

Software Mentioned

THETA
OMEGAPD
TNPRI
PRIOR
diwish
NPDE
SIGMAPD
PsN®
VPC
THETAPV

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved