Prior killing of intracellular bacteria Wolbachia reduces inflammatory reactions and improves antifilarial efficacy of diethylcarbamazine in rodent model of Brugia malayi

Parasitology Research
Shilpy ShakyaShailja Misra-Bhattacharya

Abstract

The discovery of the endosymbiont Wolbachia, which has a mutualistic relationship with filarial nematodes, and its importance in filarial parasite biology has provided a lead for developing novel chemotherapeutic agents against human filariasis. Wolbachia also appears to be involved in immunopathological responses as well as adverse reactions after antifilarial therapy. The aim of the present study was to explore the potential of administering anti-Wolbachial therapy before antifilarial treatment to improve the filaricidal efficacy of the present-day filaricide diethylcarbamazine. An additional objective was to minimize host inflammatory reactions using a rodent model Mastomys coucha and Meriones unguiculatus infected with human lymphatic filariid Brugia malayi. We observed: (1) a 40-day treatment schedule of tetracycline alone resulted in delayed reduction in microfilaraemia and a low degree of macrofilaricidal efficacy; (2) tetracycline therapy followed by 100 mg/kg diethylcarbamazine (DEC) x5 days led to marked reduction in microfilaraemia from day 48 onward after initiation of treatment. The combination treatment also brought about approximately 70% death of adult B. malayi and sterilization of 82.3% of the surviving female...Continue Reading

References

Nov 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·J P Moulia-PelatL Nicolas
Apr 16, 1998·Tropical Medicine & International Health : TM & IH·S MisraR K Chatterjee
Aug 6, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·M M IsmailA S Dissanaike
Oct 8, 1999·Parasitology Today·M J Taylor, A Hoerauf
Mar 16, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·M HaarbrinkM Yazdanbakhsh
Mar 29, 2002·The Journal of Infectious Diseases·Paul B KeiserThomas B Nutman
Jul 20, 2002·The Lancet Infectious Diseases·Dinesh C Sharma
Oct 24, 2002·International Journal for Parasitology·M CasiraghiC Bandi
Jan 14, 2003·Annual Review of Immunology·Kiyoshi TakedaShizuo Akira
Jul 16, 2003·Annals of the New York Academy of Sciences·Mark J Taylor
Mar 17, 2006·Free Radical Biology & Medicine·Marcelo G BoniniRonald P Mason
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph D TurnerMark J Taylor
Jul 25, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Gerusa DreyerJoaquim Norões
Oct 19, 2006·PLoS Pathogens·Alexander Yaw DebrahAchim Hoerauf

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Citations

Mar 24, 2011·Future Medicinal Chemistry·Prashant Kumar SinghShailja Misra-Bhattacharya
Jan 20, 2010·Trends in Microbiology·Bethany N Kent, Seth R Bordenstein
Oct 27, 2015·PLoS Neglected Tropical Diseases·Andrea M BinneboseBryan H Bellaire
Nov 30, 2020·International Immunopharmacology·Rohit Kumar TiwariPreeti Bajpai

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