Prior maze experience required to alter midazolam effects in rats submitted to the elevated plus-maze

Pharmacology, Biochemistry, and Behavior
L J Bertoglio, A P Carobrez

Abstract

In rodents, prior maze experience increases open arm avoidance (OAA) and compromises the anxiolytic effects of benzodiazepines in a subsequent exposure to the elevated plus-maze (EPM), a phenomenon referred to as "one trial tolerance" (OTT). Nevertheless, a possible correlation between these intriguing events remains unclear. Using maze-naive and maze-experienced (free exploration of the EPM for 5 min) rats, Experiment 1 confirmed the anxiolytic effects of midazolam (MDZ; 0.125-1.0 mg/kg) in maze-naive rats, while both increased OAA and OTT to the MDZ anxiolytic effects were observed in maze-experienced rats. However, our results from Experiment 2, designed to assess whether open, enclosed or both arms experience is involved in increased OAA and OTT, showed that MDZ retained its efficacy in rats confined either to an open or enclosed arm, where no significant changes in open arm exploration were observed when compared to the maze-naive group, therefore suggesting that prior experience in the whole apparatus may be involved in the loss of the anxiolytic MDZ effects. Results are discussed in terms of a possible correlation between increased OAA and the OTT phenomenon elicited in a subsequent exposure to the EPM.

References

Jan 1, 1990·Pharmacology & Therapeutics·R G Lister
Jan 1, 1987·Psychopharmacology·R G Lister
Feb 1, 1995·Trends in Pharmacological Sciences·G R Dawson, M D Tricklebank
Jan 1, 1993·Psychopharmacology·S E FileF G Graeff
Jan 1, 1993·Psychopharmacology·S L Handley, J W McBlane
Dec 20, 1993·Behavioural Brain Research·S E File
Feb 1, 1993·Pharmacology, Biochemistry, and Behavior·D TreitC Royan
May 1, 1996·Pharmacology, Biochemistry, and Behavior·C Fernandes, S E File
Jan 4, 1998·Pharmacology, Biochemistry, and Behavior·M HascoetA Couetoux du Tertre
Oct 21, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S E FileR Gallant
Dec 2, 1998·Behavioural Pharmacology·R J Rodgers
Mar 12, 1999·Neuroscience and Biobehavioral Reviews·J Menard, D Treit
Aug 5, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S E FileR Gallant
Dec 13, 2000·Pharmacology, Biochemistry, and Behavior·V P RosaM S Faria
Apr 1, 1993·Behavioural Processes·G GriebelR Misslin

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Citations

May 27, 2005·Psychopharmacology·Nadège RipollMartine Hascoët
Jun 2, 2005·Physiology & Behavior·Andrea Milena Becerra GarciaSilvio Morato
Sep 6, 2002·Pharmacology, Biochemistry, and Behavior·L J Bertoglio, A P Carobrez
Dec 14, 2002·Pharmacology, Biochemistry, and Behavior·M L C Dal-CólM S Faria
Apr 17, 2010·European Journal of Pharmacology·Brijesh G TaksandeChandrabhan T Chopde
Jul 25, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·K S Gomes, R L Nunes-De-Souza
Apr 14, 2016·Pharmacology Research & Perspectives·Abdelkader Ennaceur, Paul L Chazot
Aug 5, 2015·Physiology & Behavior·Dieferson da Costa EstrelaGuilherme Malafaia
Jul 16, 2008·Brain Research·Luciana Maria dos Reis, Azair Canto-de-Souza
Oct 27, 2004·Pharmacology, Biochemistry, and Behavior·Miroslav M SavićDubravko R Bokonjić
Jul 11, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kleber Meneghel VargasRoberto Andreatini
Aug 9, 2005·Neuroscience and Biobehavioral Reviews·A P Carobrez, L J Bertoglio
Feb 24, 2015·Neurology Research International·Hamid Azizi-MalekabadiAkbar Anaeigoudari
Oct 24, 2007·Brain Research·Rajesh R UgaleChandrabhan T Chopde
Jul 13, 2016·Behavioural Brain Research·Lokesh Verma, Nishant S Jain
Aug 22, 2006·Behavioural Brain Research·A EnnaceurP L Chazot
May 16, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Celio Estanislau, Silvio Morato
Jun 6, 2008·Pharmacology, Biochemistry, and Behavior·C A J SternL J Bertoglio
Oct 4, 2016·Environmental Science and Pollution Research International·Abraão Tiago Batista GuimarãesGuilherme Malafaia
Nov 4, 2016·Environmental Science and Pollution Research International·Joyce Moreira de SouzaGuilherme Malafaia
Sep 21, 2018·Behavior Genetics·Lucía Raily AcuñaGeison Souza Izídio
Dec 14, 2019·Scientific Reports·Lucía AméndolaDaniel M Weary

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