Prior Misdiagnosis of Celiac Disease Is Common Among Patients Referred to a Tertiary Care Center: A Prospective Cohort Study

Clinical and Translational Gastroenterology
Gianluca IaniroGiovanni Cammarota

Abstract

Interest of patients and physicians in celiac disease is growing worldwide, but without a corresponding increase in the awareness of the disease. Many patients are diagnosed as celiacs even without completing the whole diagnostic process, with consequent risk of misdiagnosis and delay in the evaluation of other diseases. The objective of this study was to assess the rates of prior celiac disease misdiagnosis among patients referred to a tertiary care center. From June 2013 to December 2014, we prospectively recruited patients referred for the first time to our Celiac Disease Center. Patients with a previous diagnosis of celiac disease underwent a diagnostic revaluation by second reading of duodenal tissue slides, dosage of specific antibodies, and/or duodenal biopsy sampling; HLA status was investigated in pertinent cases. A total of 198 subjects were recruited. Of these, 91 "naïve" patients (46%) started the diagnostic screening for celiac disease; 58 of them (64-29% of the whole sample) were diagnosed as celiacs. The remaining 107 patients (54%) came with a previous diagnosis of celiac disease: of these, 52 (49-26% of the whole sample) presented with confirmed diagnosis of celiac disease, whereas 55 (51-28% of the whole sampl...Continue Reading

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Citations

Jul 14, 2016·Journal of Community Hospital Internal Medicine Perspectives·Marcelle G MeseehaVictor O Kolade
Dec 13, 2016·Pediatric Rheumatology Online Journal·J PalmanC Pilkington
Jul 21, 2017·Journal of Clinical Gastroenterology·Margot E CohenPeter H R Green
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Aug 10, 2020·The American Journal of Gastroenterology·Katherine CappellDaniel A Leffler

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Methods Mentioned

BETA
biopsies
biopsy
ELISA

Software Mentioned

GraphPad Quickcalcs
GraphPad

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