PMID: 9160846Apr 1, 1997Paper

Prior non-spatial pretraining eliminates sensorimotor disturbances and impairments in water maze learning caused by diazepam

Psychopharmacology
Donald Peter Cain

Abstract

Diazepam has been reported to impair spatial learning in the water maze. This experiment reexamined this topic using control groups that had first been non-spatially pretrained to familiarize them with the general behavioral strategies required in the water maze task. Naive rats given diazepam (0.5, 3.0, 6.0 mg/kg, IP) displayed dose-related maze acquisition impairments and sensorimotor disturbances (swimming in the periphery of the pool, deflecting off or swimming over the hidden platform, jumping off the platform when placed there after a trial, ataxia on a narrow wooden beam). The sensorimotor disturbances interfered with the acquisition of information about the spatial location of the platform, occurred in the absence of impairments in a subsequent visible platform task or swim speed, and correlated strongly with measures of acquisition. In contrast, the non-spatially pretrained groups did not exhibit sensorimotor disturbances in the water maze and acquired the maze task as rapidly under diazepam as control rats. The non-spatially pretrained groups continued to display diazepam-induced sensorimotor disturbances (ataxia) in a novel beam walking task. CGS8216 (10.0 or 20.0 mg/kg), a benzodiazepine receptor antagonist, attenua...Continue Reading

Citations

Sep 24, 1999·Journal of Neuroscience Research·C Hölscher
Aug 23, 2001·Brain Research. Brain Research Reviews·R D'Hooge, P P De Deyn
Dec 21, 2002·Behavioural Brain Research·Timothy E HohDonald P Cain
Jun 12, 2003·Behavioural Brain Research·Manish Kumar SarafManjeet Singh
Apr 1, 1997·Current Opinion in Neurobiology·D P Cain
Jul 27, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Laura KentonDonald P Cain
Nov 27, 2009·Proceedings. Biological Sciences·Lara D LaDageVladimir V Pravosudov
Jun 11, 2009·PloS One·Marian Tsanov, Denise Manahan-Vaughan
Oct 4, 2008·Behavioural Brain Research·Maria GulinelloDonald S Faber
Jun 27, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gabriele GhisleniLisiane O Porciúncula
Apr 14, 2016·Pharmacology Research & Perspectives·Abdelkader Ennaceur, Paul L Chazot
Apr 17, 2002·Brain Research·Inga Maj JohanssonTorbjörn Bäckström
Aug 11, 2004·Pharmacology, Biochemistry, and Behavior·Yue LiuHai Wang
Jul 26, 2005·Experimental Neurology·Alexander TonkikhPeter L Carlen
Jul 6, 2010·Neuroscience·H JeonR L Macdonald
Jul 8, 2011·The International Journal of Neuropsychopharmacology·Matthew R SkeltonCharles V Vorhees
Apr 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrea J Saber, Donald P Cain

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