Abstract
Studies of young, premenopausal women suggest that changes in coronary risk factors do not persist after discontinuation of oral contraceptive use. However, little is known about longterm effects of past oral contraceptive use in older, postmenopausal women, who typically have a more atherogenic profile. This study examines the relation of past oral contraceptive use (including duration) to heart disease risk factors in postmenopausal women. Subjects were 517 women aged 50-69 from the Rancho Bernardo Study who attended follow-up clinic visits. Past oral contraceptive use was reported by 24.2% and two thirds had used oral contraceptives < or = 5 years. After adjustment for covariates, the only significant difference was that past users had higher diastolic blood pressures than never users (p < 0.01). Among older women, the diastolic blood pressure of past users was 3.9 mm Hg higher than that of never users (p < 0.01). Women who used oral contraceptives for < or = 5 years had diastolic blood pressures 3.6 mm Hg higher than those of never users (p < 0.01). No differences were found among younger women or those who used oral contraceptives > or = 6 years. Past oral contraceptive users may be at increased risk for heart disease beca...Continue Reading
References
Apr 7, 1979·Lancet·S ShapiroO S Miettinen
Sep 1, 1979·Circulation·C H HennekensE H Kass
Sep 14, 1979·JAMA : the Journal of the American Medical Association·D B PetittiS Ramcharan
Jun 6, 1977·JAMA : the Journal of the American Medical Association·I R Fisch, J Frank
Mar 1, 1978·American Journal of Epidemiology·P D StolleyR Schinnar
Aug 21, 1976·British Medical Journal·J I MannM Thorogood
May 3, 1975·British Medical Journal·J I MannS R Doll
May 3, 1975·British Medical Journal·J I Mann, W H Inman
Jun 1, 1991·The American Journal of the Medical Sciences·D A LeafC S Scott
Nov 17, 1988·The New England Journal of Medicine·M J StampferC H Hennekens
Oct 1, 1987·American Journal of Obstetrics and Gynecology·U J Gaspard
Feb 1, 1986·Contraception·A CoulterB Crossley
Jan 1, 1985·Journal of Chronic Diseases·J A PerlmanG Lieberknecht
Oct 11, 1969·Lancet·V WynnT Stokes
Nov 1, 1974·British Journal of Preventive & Social Medicine·R GlassM Vessey
May 1, 1973·American Journal of Obstetrics and Gynecology·N Phillips, T Duffy
Mar 23, 1974·British Medical Journal·R J WeirE Wilson
Nov 1, 1971·The Journal of Clinical Endocrinology and Metabolism·B Desbuquois, G D Aurbach
Mar 1, 1983·International Journal of Epidemiology·M J RosenbergG L Rubin
Aug 20, 1981·The New England Journal of Medicine·D SloneP D Stolley
Feb 1, 1980·Circulation·G HeissI D Frantz
Jan 1, 1980·American Journal of Epidemiology·L RosenbergF E Speizer
Nov 1, 1993·American Journal of Epidemiology·P NischanU Hirsch
Citations
Aug 18, 1999·British Journal of Sports Medicine·K BennellK Crossley
Oct 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Latanya M ScottJ Mark Cline
Aug 9, 2005·International Journal of Cardiology·Per Otto SchuellerMichael Christ