Prior placental bed disorders and later dementia: a retrospective Swedish register-based cohort study

BJOG : an International Journal of Obstetrics and Gynaecology
Ellika G AndolfGunilla C M Sydsjö

Abstract

To investigate the association between a history of placental bed disorders and later dementia. Retrospective population-based cohort study. Sweden. All women giving birth in Sweden between 1973 and 1993 (1 128 709). Women with and without placental bed disorders (hypertensive disorders of pregnancy including pre-eclampsia, fetal growth restriction, spontaneous preterm labour and birth, preterm premature rupture of membranes, abruptio placenta, late miscarriages) and other pregnancy complications were identified by means of the Swedish Medical Birth Register. International classification of disease was used. Data were linked to other National Registers. Participants were followed up until 2013. The Cox proportional hazards model was used to calculate hazard ratios for women with and without pregnancy complications and were adjusted for possible confounders. Diagnosis of vascular dementia and non-vascular dementia. Adjusted for cardiovascular disease and socio-demographic factors, an increased risk of vascular dementia was shown in women with previous pregnancy-induced hypertension (Hazard ratio [HR] 1.88, 95% CI 1.32-2.69), pre-eclampsia (HR 1.63, 95% CI 1.23-2.16), spontaneous preterm labour and birth (HR 1.65, 95% CI 1.12-2.4...Continue Reading

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Citations

Jul 7, 2021·Current Neurology and Neuroscience Reports·Amalia Peterson, Sarah E Tom
Aug 7, 2021·Scientific Reports·Shibin ChengSurendra Sharma
Aug 28, 2021·American Journal of Hypertension·Carmel M McEniery

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