Prior segregation analysis and the power to detect linkage

Genetic Epidemiology
L D Atwood, S H Slifer

Abstract

Complex parametric segregation and linkage analysis was performed on the simulated quantitative trait Q1 for all 200 replicates of the nuclear families data set. The segregation analysis inferred a major gene in 46% of the replicates. Among all replicates, including those that rejected a major gene, the power to detect suggestive linkage to any of three loci affecting Q1 was 0.600 and the false positive rate was 0.002. Among the replicates where a major gene was found, the power to detect suggestive linkage was 0.652 and the false positive rate was also 0.002. Thus, for purposes of linkage to this complex trait, a prior segregation then linkage analysis approach located a gene in 30% of all replicates, whereas a linkage only approach located a gene in 60% of all replicates.

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References

Jan 1, 1992·Genetic Epidemiology·V J VielandD A Greenberg
Dec 1, 1989·American Journal of Medical Genetics·R C Elston
Jan 1, 1995·Genetic Epidemiology·L D AtwoodN C Stowell

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Citations

Aug 30, 2000·Genetic Epidemiology·S Ghosh, P P Majumder
Mar 20, 2001·Genetic Epidemiology·L D AtwoodJ W MacCluer
Mar 4, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·E M WijsmanS S Deeb
Mar 7, 2001·Hypertension·L D AtwoodJ W MacCluer

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