Prior statin use has no effect on survival after intracerebral hemorrhage in a multiethnic Asian patient cohort

Acta Neurochirurgica. Supplement
Nicolas K K KingBeng-Ti Ang

Abstract

Statins have been shown to reduce mortality and morbidity in ischemic stroke, subarachnoid hemorrhage, and traumatic brain injuries, but their effect on intracerebral hemorrhage (ICH) remains to be determined. This study aimed to investigate the effect of prior statin use on survival following spontaneous primary intracerebral hemorrhage in a multi-ethnic Asian population. A study cohort of patients admitted with spontaneous primary ICH was obtained from our database. There were 1,381 patients who met the inclusion criteria. Multivariate logistic regression was used to identify independent predictors and computed odds ratios for 30-day mortality. Kaplan-Meier and Cox proportional hazard survival analyses were used to examine the effect of prior statin use on survival after ICH. Multivariate logistic regression controlling for baseline characteristics and in-hospital interventions, did not demonstrate any effect of prior statin use (p = 0.781) on mortality. Survival analyses also failed to demonstrate any differences in survival after ICH with prior statin use. Similarly subgroup analyses showed no difference. No beneficial effect on survival after ICH of prior statin use could be demonstrated in our large multi-ethnic Asian pat...Continue Reading

Citations

Aug 27, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Jin-Man JungWoo-Keun Seo
Dec 20, 2015·Pharmacotherapy·Andrea Sikora NewsomeEmily A Durr
Sep 18, 2015·Neurologia i neurochirurgia polska·Dariusz KotlęgaPrzemysław Nowacki
Jul 24, 2018·Current Vascular Pharmacology·S MohammadJ P Kitzmiller
Jun 2, 2016·Brain and Behavior·Shu-Yu TaiChen-Yu Chien
Apr 23, 2014·CNS Neuroscience & Therapeutics·Yue-Song PanUNKNOWN CNSR investigators
Oct 15, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C LeiY Chen

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