PMID: 2508160Jan 1, 1989Paper

Prior stress attenuates the analgesic response but sensitizes the corticosterone and cortical dopamine responses to stress 10 days later

Psychopharmacology
A R CaggiulaD J Edwards

Abstract

This study demonstrates that pre-exposure to stress influences subsequent effects of stress on pain sensitivity (stress-induced analgesia) and on plasma corticosterone and brain catecholamine activity. Animals exposed to a 30 min shock session (S1 = 8, 5.0 s shocks) 10 days earlier showed a significant attenuation of shock-induced analgesia, as measured by increased latency of tail withdrawal from a hot water bath immediately after a 40 s, 1.6 mA footshock (S2). Animals exposed to shock 10 days before testing also exhibited a higher plasma corticosterone response to testing than did all other groups. Norepinephrine (NE) levels in the frontal cortex and dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) levels in the frontal cortex and nucleus accumbens were not altered in any group. However, the DOPAC/DA ratio in the frontal cortex was increased by analgesia testing, and this increase was enhanced only by the combination of shock 10 days before testing and shock immediately before the test (S1 + S2). These results are consistent with previous reports from this laboratory which indicate that an animal's acute response to stress is strongly influenced by its past history of stress.

References

Jul 1, 1975·Journal of Comparative and Physiological Psychology·S Siegel
Jan 1, 1989·Psychopharmacology·L H EpsteinR Stiller
Jan 1, 1989·Psychopharmacology·A R CaggiulaR Stiller
Nov 1, 1985·Pharmacology, Biochemistry, and Behavior·C A Hendrie
Jan 1, 1988·Annals of the New York Academy of Sciences·S M AntelmanD J Edwards
Aug 20, 1986·Brain Research·S Puglisi-AllegraA Oliverio
Aug 1, 1985·Biological Psychiatry·M L Sedlock, D J Edwards
Apr 1, 1984·Behavioral Neuroscience·J E ShermanJ W Lewis
May 9, 1980·Science·J W LewisJ C Liebeskind
Sep 1, 1980·Pharmacology, Biochemistry, and Behavior·T G HeffnerL S Seiden

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Citations

May 10, 2002·Depression and Anxiety·Eric Vermetten, J Douglas Bremner
Apr 1, 1993·Biological Psychiatry·R Yehuda, S M Antelman
Apr 1, 1992·Physiology & Behavior·H H Van DijkenF J Tilders
Nov 1, 1994·Physiology & Behavior·R J ServatiusB H Natelson
Feb 1, 1994·Pharmacology, Biochemistry, and Behavior·C FahlkeE Hård
Oct 12, 2002·Pharmacology, Biochemistry, and Behavior·Marcela B EcheverryElaine A Del Bel
Jan 7, 1998·Neuroscience and Biobehavioral Reviews·J M KoolhaasB Bohus
Apr 9, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·S M Antelman, S Gershon
Jun 5, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·A R CaggiulaR Stiller
Sep 22, 2005·Experimental and Clinical Psychopharmacology·Frances K McSweeneyBenjamin P Kowal
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P V PiazzaH Simon
May 15, 2002·Scandinavian Journal of Psychology·Barbara A Sorg, David B Newlin
Jun 21, 1997·Annals of the New York Academy of Sciences·A M Rasmusson, D S Charney
Oct 17, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christina Chotiwat, Ruth B S Harris
Aug 25, 2015·Stress : the International Journal on the Biology of Stress·Xavier BeldaAntonio Armario
Apr 23, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·H P Rome, J D Rome
Mar 14, 2007·Neuroscience and Biobehavioral Reviews·Rianne Stam
Dec 15, 2006·Pain Practice : the Official Journal of World Institute of Pain·K VissersT Meert
Jul 28, 2006·Hormones and Behavior·Christina Chotiwat, Ruth B S Harris
Mar 1, 2008·General and Comparative Endocrinology·John H BrewerC Loren Buck

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