Prior therapy with antiplatelet agents is not associated with outcome in patients with acute ischemic stroke/TIA.

Journal of Neurology
S GreiseneggerW Lalouschek

Abstract

It is unclear whether prior therapy with antiplatelet agents (APA) is associated with a better outcome in patients with acute ischemic cerebrovascular events. Within a multi-center cross-sectional study, nested in a cohort we analyzed the relation between prior therapy with APA and stroke severity in 1643 patients with acute ischemic stroke or TIA. Clinical severity of the vascular event was evaluated by the National Institutes of Health Stroke Scale on admission (NIHSS1) and after 1 week (NIHSS2). By means of analysis of variance we analyzed a possible association of APA with stroke severity and interactions regarding stroke severity between APA and other clinical measures. 475 patients (29 %) received aspirin prior to the cerebrovascular event, 51 patients (3 %) ticlopidine or clopidogrel and 26 patients (1.6%) aspirin combined with extended release dipyridamole. 66% (1091) of patients did not take any antiplatelet medication. Neither the NIHSS1 nor the NIHSS2 nor the change of stroke severity between these time points (NIHSS1- NIHSS2) was associated with prior APA medication. We did not find significant interactions between APA use and clinical measures regarding stroke severity. Our results do not indicate that prior therap...Continue Reading

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Citations

Jun 1, 2011·Translational Stroke Research·Christopher D d'EsterreTing-Yim Lee
Sep 12, 2006·Journal of Thrombosis and Haemostasis : JTH·M PaciaroniS Biagini
Oct 20, 2010·Annals of the New York Academy of Sciences·C D d'Esterre, T-Y Lee
Mar 13, 2018·European Heart Journal. Cardiovascular Pharmacotherapy·Morten WürtzHenrik Toft Sørensen

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