Prior tonsillectomy is associated with an increased risk of esophageal adenocarcinoma

PloS One
Katherine S GarmanShannon J McCall

Abstract

Esophageal cancer is a deadly cancer with 5-year survival <20%. Although multiple risk factors for esophageal adenocarcinoma (EAC) including obesity, GERD and smoking have been identified, these risk factors do not fully explain the rising incidence of EAC. In this study, we evaluated the association between prior history of tonsillectomy and EAC. Our goal was to determine whether tonsillectomies were more frequent in patients with EAC (cases) than in our thoracic surgery controls. Cases included 452 esophagectomy cases, including 396 with EAC and 56 who underwent esophagectomy for Barrett's esophagus (BE) with high grade dysplasia (HGD). 1,102 thoracic surgery patients with surgical indications other than dysplastic BE or esophageal cancer represented the controls for our analysis. The association of tonsillectomy and HGD/EAC were primarily evaluated by using univariate tests and then verified by logistic regression analysis. Baseline demographics, medical history, and thoracic surgery controls were compared by using χ2 tests or 95% CIs. Significant risk factors were considered as covariates in the multivariate models while evaluating the association between tonsillectomy and HGD/EAC. P-values or odds ratios were estimated wit...Continue Reading

References

Jan 1, 1988·Journal of Clinical Epidemiology·E A KrallJ Gardner
Jan 1, 1994·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·A BöckK R Herkner
Jan 1, 1993·International Journal of Pediatric Otorhinolaryngology·C S Derkay
Nov 15, 2000·Swiss Surgery = Schweizer Chirurgie = Chirurgie Suisse = Chirurgia Svizzera·P Gertsch
Jan 20, 2005·Journal of the National Cancer Institute·Heiko Pohl, H Gilbert Welch
Jan 27, 2006·World Journal of Gastroenterology : WJG·Zhiheng PeiMartin J Blaser
Apr 24, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Juan Carlos Andreu-BallesterCarlos Peñarroja Otero
Feb 26, 2008·Cancer Science·Shin Maeda, Masao Omata
Dec 3, 2010·The New England Journal of Medicine·Amy Berrington de GonzalezMichael J Thun
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Apr 22, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Reginald F BaughUNKNOWN American Academy of Otolaryngology-Head and Neck Surgery Foundation
Aug 23, 2011·Journal of Clinical Gastroenterology·Robert J BasseriMark Pimentel
Oct 15, 2011·The New England Journal of Medicine·Frederik Hvid-JensenPeter Funch-Jensen
Jun 2, 2012·Frontiers in Oncology·Aaron P ThriftDavid C Whiteman
Sep 17, 2013·World Journal of Gastroenterology : WJG·Yuwei Zhang
Apr 5, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Guoqin YuChristian C Abnet
Dec 3, 2014·Clinics in Laboratory Medicine·Jonathan BaghdadiLiying Yang
Dec 30, 2014·The New England Journal of Medicine·Anil K Rustgi, Hashem B El-Serag
Sep 5, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ben BoursiYu-Xiao Yang
Dec 19, 2015·Journal of Gastroenterology and Hepatology·Weili SunChuanhua Yang
Mar 16, 2016·British Journal of Cancer·Jose P ZevallosAndrew F Olshan
Nov 1, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kensuke YamamuraHideo Baba
Apr 14, 2017·The Lancet. Gastroenterology & Hepatology·Daffolyn R Fels ElliottRebecca C Fitzgerald
Apr 14, 2017·The Lancet. Gastroenterology & Hepatology·Julian A Abrams
Mar 5, 2018·International Journal of Pediatric Otorhinolaryngology·Luisa ZupinSergio Crovella
Jul 31, 2018·Lancet·Janusz A Z JankowskiUNKNOWN AspECT Trial Team

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