Prioritising pharmaceuticals for environmental risk assessment: Towards adequate and feasible first-tier selection

The Science of the Total Environment
V RoosC Rudén

Abstract

The presence of pharmaceuticals in the aquatic environment, and the concerns for negative effects on aquatic organisms, has gained increasing attention over the last years. As ecotoxicity data are lacking for most active pharmaceutical ingredients (APIs), it is important to identify strategies to prioritise APIs for ecotoxicity testing and environmental monitoring. We have used nine previously proposed prioritisation schemes, both risk- and hazard-based, to rank 582 APIs. The similarities and differences in overall ranking results and input data were compared. Moreover, we analysed how well the methods ranked seven relatively well-studied APIs. It is concluded that the hazard-based methods were more successful in correctly ranking the well-studied APIs, but the fish plasma model, which includes human pharmacological data, also showed a high success rate. The results of the analyses show that the input data availability vary significantly; some data, such as logP, are available for most API while information about environmental concentrations and bioconcentration are still scarce. The results also suggest that the exposure estimates in risk-based methods need to be improved and that the inclusion of effect measures at first-tier...Continue Reading

References

May 7, 1998·Chemosphere·B Halling-SørensenS E Jørgensen
Dec 11, 1999·Environmental Health Perspectives·C G Daughton, T A Ternes
Mar 26, 2004·Regulatory Toxicology and Pharmacology : RTP·Hans SandersonKeith R Solomon
Nov 1, 2005·Aquatic Toxicology·Karl FentDaniel Caminada
Feb 10, 2007·Regulatory Toxicology and Pharmacology : RTP·Sven Ove Hansson, Christina Rudén
Aug 21, 2007·Journal of Hazardous Materials·D G Joakim LarssonNicklas Paxeus
Oct 16, 2007·The Science of the Total Environment·Mitchell S Kostich, James M Lazorchak
Jan 19, 2008·Environmental Science & Technology·Gerald T AnkleyJohn P Sumpter
Apr 29, 2008·The Science of the Total Environment·Emily R CooperKarl Phillips
May 17, 2008·Endocrinology·Solange Miguel-Queralt, Geoffrey L Hammond
Jun 20, 2008·Integrated Environmental Assessment and Management·Stefan A E KoolsThomas Knacker
Aug 30, 2008·Environmental Science & Technology·Lina GunnarssonD G Joakim Larsson
May 20, 2009·Environmental Toxicology and Chemistry·Jerker FickD G Joakim Larsson
May 28, 2009·Environmental Toxicology and Chemistry·Jana ZeilingerReinhard Länge
Aug 12, 2009·Environmental Toxicology and Chemistry·Theodore W ValentiBryan W Brooks
Nov 17, 2009·Environmental Toxicology and Chemistry·Bryan W BrooksAlistair B A Boxall
Dec 4, 2009·Journal of Hazardous Materials·Lúcia H M L M SantosM C B S M Montenegro
Jul 14, 2010·The Science of the Total Environment·Mitchell S KostichJames M Lazorchak
Aug 20, 2010·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Sierra Rayne, Kaya Forest
Sep 8, 2010·Regulatory Toxicology and Pharmacology : RTP·Jerker FickD G Joakim Larsson
Jun 21, 2011·Environmental Toxicology and Chemistry·Filip CuklevD G Joakim Larsson
Nov 1, 2007·Environmental Toxicology and Pharmacology·Jeffrey N BrownD G Joakim Larsson

❮ Previous
Next ❯

Citations

Feb 20, 2014·Indian Journal of Pharmacology·Jun Wang, Xiamin Hu
Apr 27, 2013·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Gisela HolmPernilla Sörme
Jul 3, 2013·Journal of Hazardous Materials·Francesc FàbregaMartí Nadal
Jun 9, 2012·Analytical and Bioanalytical Chemistry·B HuertaD Barceló
Feb 26, 2016·Environmental Pollution·James P MeadorEvan P Gallagher
Jan 23, 2016·Environmental Toxicology and Chemistry·Jiahua GuoAlistair B A Boxall
Nov 10, 2012·Environment International·Rik OldenkampAd M J Ragas
Jun 23, 2012·Journal of Hazardous Materials·Filip CuklevD G Joakim Larsson
Sep 8, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Lan WangShuang Bao
Aug 21, 2014·Environmental Toxicology and Chemistry·A Ross Brown
Mar 21, 2016·The Science of the Total Environment·Fatima MansourDarine Salam
Sep 9, 2015·Environmental Toxicology and Chemistry·Kyunghee JiKyungho Choi
Mar 24, 2016·Bulletin of Environmental Contamination and Toxicology·Gopinath NallaniDuane Huggett
Mar 24, 2016·Environmental Toxicology and Chemistry·Mike WilliamsTim Verslycke
Aug 19, 2015·Environmental Toxicology and Pharmacology·Viktoriia BurkinaGalia Zamaratskaia
May 7, 2015·Critical Reviews in Toxicology·Matthew D OverturfDouglas A Holdway
Feb 8, 2014·Aquatic Toxicology·Bryan W Brooks
Jun 18, 2014·The Science of the Total Environment·Mustafa Al AukidyNikolaos Voulvoulis
Feb 24, 2015·Ecotoxicology and Environmental Safety·Milena WawryniukGrzegorz Nałęcz-Jawecki
Jan 26, 2017·Integrated Environmental Assessment and Management·Bakhyt AubakirovaAlistair Ba Boxall
May 10, 2017·Environmental Toxicology and Chemistry·Emily E BurnsAlistair B A Boxall
May 2, 2018·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Emily E BurnsAlistair B A Boxall
Sep 21, 2017·Environmental Science and Pollution Research International·André Luiz PereiraSandra Rosa Pereira
May 4, 2016·Environmental Science and Pollution Research International·Omar S A Al-Khazrajy, Alistair B A Boxall
Jan 1, 2013·Environmental Science. Processes & Impacts·Indrani MahapatraJamie R Lead
Nov 19, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kathryn E ArnoldJohn P Sumpter
Nov 19, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D G Joakim Larsson
Nov 19, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A R BrownC R Tyler
Nov 19, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anette Küster, Nicole Adler
Nov 19, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Carlie A LaLoneGerald T Ankley
Feb 8, 2020·Environmental Toxicology and Chemistry·Margaret E McArdleAudrey J Bone
Mar 6, 2015·The AAPS Journal·Usman Khan, Jim Nicell
Dec 6, 2018·Environmental Science and Pollution Research International·Sarah Letsinger, Paul Kay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Environmental Science & Technology
Mariann Rand-WeaverJohn P Sumpter
Water Science and Technology : a Journal of the International Association on Water Pollution Research
P de VoogtM Mons
Environmental Science & Technology
Gerald T AnkleyJohn P Sumpter
© 2022 Meta ULC. All rights reserved