Prioritizing human pharmaceuticals for ecological risks in the freshwater environment of Korea

Environmental Toxicology and Chemistry
Kyunghee JiKyungho Choi

Abstract

Pharmaceutical residues are potential threats to aquatic ecosystems. Because more than 3000 active pharmaceutical ingredients (APIs) are in use, identifying high-priority pharmaceuticals is important for developing appropriate management options. Priority pharmaceuticals may vary by geographical region, because their occurrence levels can be influenced by demographic, societal, and regional characteristics. In the present study, the authors prioritized human pharmaceuticals of potential ecological risk in the Korean water environment, based on amount of use, biological activity, and regional hydrologic characteristics. For this purpose, the authors estimated the amounts of annual production of 695 human APIs in Korea. Then derived predicted environmental concentrations, using 2 approaches, to develop an initial candidate list of target pharmaceuticals. Major antineoplastic drugs and hormones were added in the initial candidate list regardless of their production amount because of their high biological activity potential. The predicted no effect concentrations were derived for those pharmaceuticals based on ecotoxicity information available in the literature or by model prediction. Priority lists of human pharmaceuticals were de...Continue Reading

References

Sep 2, 2000·The Journal of Antimicrobial Chemotherapy·B Halling-SørensenF Ingerslev
Apr 15, 2003·Toxicology Letters·Simon WebbKlaus Olejniczak
Feb 19, 2004·Environmental Science & Technology·Paul D AndersonBradley W Schwab
Mar 26, 2004·Regulatory Toxicology and Pharmacology : RTP·Hans SandersonKeith R Solomon
Feb 22, 2005·Environmental Toxicology and Chemistry·April A RobinsonMichael J Lydy
May 6, 2005·Environmental Science & Technology·Jay TunkelPhilip Howard
Jun 28, 2005·Regulatory Toxicology and Pharmacology : RTP·Bradley W SchwabPaul D Anderson
Jul 5, 2005·The Science of the Total Environment·Marina IsidoriAlfredo Parrella
Oct 20, 2005·SAR and QSAR in Environmental Research·E HulzebosL Maslankiewicz
Oct 16, 2007·The Science of the Total Environment·Mitchell S Kostich, James M Lazorchak
Apr 29, 2008·The Science of the Total Environment·Emily R CooperKarl Phillips
Jan 13, 2009·Environment International·Marina IsidoriFabio Temussi
Aug 4, 2009·Environmental Toxicology and Chemistry·Robert HannahJohn P Sumpter
Nov 4, 2009·Regulatory Toxicology and Pharmacology : RTP·Virginia L CunninghamRudolf Bechter
Sep 8, 2010·Regulatory Toxicology and Pharmacology : RTP·Jerker FickD G Joakim Larsson
Oct 18, 2011·Environmental Toxicology and Chemistry·Jerome M DiamondKaren A Kidd
Dec 14, 2011·Integrated Environmental Assessment and Management·Virginia L CunninghamNeil J Parke
Jun 1, 2012·Environmental Health Perspectives·Alistair B A BoxallGlen Van Der Kraak
Jul 21, 2012·Regulatory Toxicology and Pharmacology : RTP·Zhao DongJames P Shine
Nov 10, 2012·Environment International·Rik OldenkampAd M J Ragas
Jul 16, 2014·The Science of the Total Environment·Maja KuzmanovićDamia Barceló
Nov 2, 2014·Environmental Toxicology and Chemistry·Nicholas J NiemuthRebecca D Klaper

❮ Previous
Next ❯

Citations

Mar 24, 2016·Environmental Toxicology and Chemistry·Mike WilliamsTim Verslycke
May 10, 2017·Environmental Toxicology and Chemistry·Emily E BurnsAlistair B A Boxall
Mar 21, 2017·The Science of the Total Environment·Eun Jeong Han, Dong Soo Lee
Dec 24, 2018·The Science of the Total Environment·Yan LiJie Ding
Nov 15, 2020·Environmental Science and Pollution Research International·Qingwei BuGang Yu
Jul 14, 2021·Environmental Research·Antonietta SicilianoMarina DellaGreca
Apr 14, 2018·Environmental Science & Technology·Laura W MatzekKimberly E Carter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.