Prk1p

The International Journal of Biochemistry & Cell Biology
G Zeng, Mingjie Cai

Abstract

The protein kinase Prk1p (standing for p53 regulating kinase 1) of the yeast Saccharomyces cerevisiae is the prototype of a kinase family identified recently as important regulators of the actin cytoskeleton and endocytosis. These kinases all have a highly homologous serine/threonine kinase domain in their N-terminal region but share no significant homology in other regions. Prk1p also contains a proline-rich motif near its C-terminus that is required for the proper subcellular localization of the protein. The kinase activity of Prk1p has been confirmed by both in vitro and in vivo studies and shown to be essential for the protein's function. To date, several proteins that play essential roles in actin cytoskeleton organization and endocytosis have been identified as the regulatory targets of Prk1p. Phosphorylation on the [L/I/V/N]xx[Q/N/T/S]xTG motifs by Prk1p results in a down-regulation of the functions of these target proteins. The observation that many yeast proteins involved in the actin cytoskeleton organization and endocytosis contain the Prk1p phosphorylation motifs has led to the hypothesis that the Prk1p family of kinases are possibly the general regulators of the actin cytoskeleton and endocytosis in yeast.

References

Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·S ThiagalingamB Vogelstein
Jul 4, 2001·Nature Cell Biology·M C DuncanD G Drubin
Nov 6, 2001·Molecular Biology of the Cell·H A WatsonB Wendland
Oct 3, 2002·The Journal of Biological Chemistry·Ji Suk ChangSandra K Lemmon
Mar 14, 2003·EMBO Reports·Elizabeth Smythe, Kathryn R Ayscough
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Asa E Y Engqvist-Goldstein, David G Drubin

❮ Previous
Next ❯

Citations

Aug 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Michal SkruznyMarko Kaksonen
Mar 5, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tsutomu Takahashi
Mar 2, 2013·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tsutomu Takahashi
Jan 23, 2018·PLoS Pathogens·Guangfei TangZhonghua Ma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Actin-binding Proteins

Actin-binding proteins are a component of the actin cytoskeleton that play essential roles in cellular functions such as regulation of actin polymerization, maintenance of cell polarity, gene expression regulation, cell motility and many more functions. Discover the latest research on actin-binding proteins here.