PRMT9 promotes hepatocellular carcinoma invasion and metastasis via activating PI3K/Akt/GSK-3β/Snail signalling

Cancer Science
Hai JiangJunyao Xu

Abstract

Protein arginine methyltransferases (PRMTs) catalyse protein arginine methylation and play an important role in many biological processes. Aberrant PRMT expression in tumour cells has been documented in several common cancer types; however, its precise contribution to hepatocellular carcinoma (HCC) cell invasion and metastasis is not fully understood. In this study, we identified a new oncogene, PRMT9, whose overexpression strongly promotes HCC invasion and metastasis. PRMT9 expression was detected more frequently in HCC tissues than in adjacent noncancerous tissues. PRMT9 overexpression was significantly correlated with hepatitis B virus antigen (HBsAg) status, vascular invasion, poor tumour differentiation and advanced TNM stage. Patients with higher PRMT9 expression had a shorter survival time and higher recurrence rate. PRMT9 expression was an independent and significant risk factor for survival after curative resection. Functional studies demonstrated that PRMT9 increased HCC cell invasion and lung metastasis. Knocking down PRMT9 with short hairpin RNA (shRNA) inhibited HCC cell invasion. Further investigations found that PRMT9 increased cell migration and invasion through the epithelial-mesenchymal transition (EMT) by reg...Continue Reading

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Jan 9, 2019·Journal of Molecular Endocrinology·Shu-Ching M WangGeorge E O Muscat
Jun 22, 2019·Cellular and Molecular Life Sciences : CMLS·Rui LiDing-Sheng Jiang
Dec 12, 2019·Molecular Neurobiology·Alexandre Couto E SilvaHung Wen Lin
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Methods Mentioned

BETA
surgical resection
PCR

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