Pro - inflammatory cytokines and metalloproteinase activation in polypropylene mesh implant in rat subcutaneous tissue

International Braz J Urol : Official Journal of the Brazilian Society of Urology
Elaine Bronzatto, Cassio Riccetto

Abstract

Polypropylene meshes have been increasingly adopted for correction of pelvic organ prolapse due to its lower recurrence rate when compared to surgeries without meshes. The study of the interaction of these materials with the host tissue may contribute to the development of materials with best biocompatibility and, consequently, less complication rates. The present study compares the inflammatory reaction of standard-weight (SW) and lightweight (LW) meshes (72 g/m216g/m2 respectively), implanted in the abdomen of 20 adult rats, which were euthanized in four or 30 days. Quantification of pro-inflammatory markers, IL-1 and TNF-α, and of metalloproteinases, MMP2 and MMP3, were carried out through immunohistochemistry with AxioVision ® software. There were no significant differences in the quantification of IL-1 and TNF-α in LW versus SW meshes. However, IL-1 quantification increased along time (30 days >4 days, p=0.0269). Also, MMP-2 quantification was similar to SW and LW and both presented a significant increase along time (30 days >4 days, p < 0.0001). MMP-3 quantification also showed no difference between the SW and LW groups, but increased along time (30 days >4 days, p=0.02). Mesh's density did not influence the quantificatio...Continue Reading

References

Oct 2, 2002·Molecular Biotechnology·J Frederick Woessner
Nov 9, 2004·International Immunopharmacology·Yoshinori IbaTohru Masukawa
Jan 5, 2006·International Urogynecology Journal and Pelvic Floor Dysfunction·X DeffieuxH Fernandez
Jun 27, 2006·Journal of Cellular and Molecular Medicine·D C JingaCristiana Matache
Jan 12, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Petra Lynen JansenPeter R Mertens
Dec 20, 2008·American Journal of Surgery·Antonio Britto CasanovaManoel Roberto Maciel Trindade
Aug 13, 2011·Hernia : the Journal of Hernias and Abdominal Wall Surgery·A CodaS Martorana
Mar 21, 2012·International Urogynecology Journal·Hiren PatelGina Sternschuss
Apr 8, 2015·International Journal of Women's Health·Patrick Dällenbach
Apr 29, 2015·Plastic and Reconstructive Surgery·Melanie R MajorGeoffrey C Gurtner
May 9, 2015·Post Reproductive Health·Smita RajshekharUwe Klinge
Jun 25, 2015·Acta Cirúrgica Brasileira·Edivaldo Massazo UtiyamaEdna Frasson de Souza Montero

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Citations

Jul 12, 2020·International Urogynecology Journal·Tsia-Shu LoKai Lyn Ng
Aug 29, 2020·The Journal of Craniofacial Surgery·Bashar AbuzayedKhaled Alawneh

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