Abstract
Inhalation of traffic-related particulate matter (e.g., diesel exhaust particles [DEPs]) is associated with acute inflammatory responses in the lung, and it promotes the development and aggravation of allergic airway diseases. We previously demonstrated that exposure to DEP was associated with increased recruitment and maturation of monocytes and conventional dendritic cells (DCs), resulting in TH2 polarization. Monocytes and immature DCs express the G-protein coupled receptor chemR23, which binds the chemoattractant chemerin. Using chemR23 knockout (KO) and corresponding wild-type (WT) mice, we determined the role of chemR23 signaling in response to acute exposure to DEPs and in response to DEP-enhanced house dust mite (HDM)-induced allergic airway inflammation. Exposure to DEP alone, as well as combined exposure to DEP plus HDM, elevated the levels of chemerin in the bronchoalveolar lavage fluid of WT mice. In response to acute exposure to DEPs, monocytes and monocyte-derived DCs accumulated in the lungs of WT mice, but this response was significantly attenuated in chemR23 KO mice. Concomitant exposure to DEP plus HDM resulted in allergic airway inflammation with increased eosinophilia, goblet cell metaplasia, and TH2 cytokin...Continue Reading
References
Aug 1, 1994·Journal of Applied Physiology·A BaiM Okazawa
Dec 10, 1999·The Journal of Allergy and Clinical Immunology·D Diaz-SanchezA Saxon
Oct 8, 2003·The Journal of Experimental Medicine·Valérie WittamerDavid Communi
Feb 25, 2005·The Journal of Experimental Medicine·William VermiSilvano Sozzani
Mar 9, 2005·The Journal of Experimental Medicine·Makoto AritaCharles N Serhan
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Valérie WittamerDavid Communi
Aug 13, 2005·The Journal of Biological Chemistry·Brian A ZabelEugene C Butcher
Jan 5, 2007·Blood·Silvia ParoliniSilvano Sozzani
Jan 15, 2008·Biochemical and Biophysical Research Communications·Haruka AokiMasatomo Mori
Apr 9, 2008·The Journal of Experimental Medicine·Jenna L CashDavid R Greaves
Jun 24, 2008·Nature Immunology·Oliver HaworthBruce D Levy
Aug 30, 2008·Journal of Leukocyte Biology·Aude GuillabertDavid Communi
Oct 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Souphalone LuangsayMarc Parmentier
Dec 2, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sharen ProvoostKurt G Tournoy
Jan 5, 2010·Biochemical and Biophysical Research Communications·Jaspreet KaurHarpal S Randeva
Jan 23, 2010·Respiratory Research·Tania MaesGuy F Joos
Mar 25, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tine DemoorGuy F Joos
Aug 17, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sharen ProvoostKurt G Tournoy
Sep 13, 2011·The Journal of Allergy and Clinical Immunology·Sharen ProvoostKurt G Tournoy
Nov 11, 2011·PLoS Pathogens·Benjamin BondueMarc Parmentier
Nov 29, 2011·Cytokine & Growth Factor Reviews·Benjamin BondueMarc Parmentier
Dec 12, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J L RourkeC J Sinal
Jan 29, 2013·Immunity·Maud PlantingaBart N Lambrecht
Oct 30, 2013·European Journal of Immunology·Bart N Lambrecht, Hamida Hammad
Dec 19, 2013·Clinical Science·Rylie P FlesherRakesh K Kumar
Mar 25, 2014·The Journal of Biological Chemistry·Jamie R DoyleAlan S Kopin
Apr 15, 2014·Cellular & Molecular Immunology·Yuli LinRui He
Apr 25, 2014·Allergy·L ZhaoR He
May 6, 2014·Lancet·Michael Guarnieri, John R Balmes
Citations
Dec 16, 2017·Physiological Reports·Farhan MalikRichard A Johnston
May 18, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K C De GroveT Maes
Aug 31, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Katrien C De GroveTania Maes
Jun 16, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stephanie W WattsGregory D Fink
May 31, 2018·Shock·Run ZouJun Zhou
Mar 7, 2020·European Journal of Immunology·Chaoming WangXiaopeng Qi
Sep 16, 2017·Scientific Reports·Smitha KumarTania Maes
Feb 21, 2019·Journal of Cellular and Molecular Medicine·Jin ShangZhanzheng Zhao
Nov 30, 2019·Frontiers in Pharmacology·Chongyang WangGuanghai Yan
Apr 24, 2018·Oncotarget·Georgios K DimitriadisHarpal S Randeva
Apr 28, 2020·BioMed Research International·Jian LiWeibing Wu
Aug 22, 2017·Frontiers in Molecular Neuroscience·Beatrice OehlerHeike L Rittner
Feb 23, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Brita Kilburg-BasnyatKymberly M Gowdy
Dec 9, 2020·Journal of Periodontology·Yusi YeLan Huang