Pro-angiogenic efficacy of transplanting endothelial progenitor cells for treating hindlimb ischemia in hyperglycemic rabbits

Journal of Diabetes and Its Complications
Ping YuManhui Pang


To evaluate the effectiveness of endothelial progenitor cells (EPCs) therapy in ischemia with or without hyperglycemia. Japanese White Rabbits were randomly assigned to three groups, group SH, hyperglycemia with sham therapy (n=10); group NE, normoglycemia with autologous EPCs transplantation therapy (n=12); and group HE, hyperglycemia with autologous EPCs transplantation therapy (n=12). Hyperglycemia was induced by injecting alloxan and sustained for 12weeks. Hindlimb ischemia was induced by complete excision of the femoral artery. Ex vivo-expanded EPCs were derived from autologous bone marrow and transplanted intermuscularily in the ischemic hindlimb. Fourteen days after transplantation, the indicators were determined. There is no difference of the functions of ex vivo-expanded EPCs from autologous bone marrow between normoglycemic and hyperglycemic groups. We found significant improvement in both EPCs transplantation therapy groups compared to sham, in terms of the angiogenesis index (8.62±1.36, 11.12±2.23, 12.35±2.97), capillary density (7.06±0.91, 13.51±1.16, 13.90±2.78), capillary to muscle fiber ratio (0.68±0.09, 0.96±0.11,0.89±0.10), muscle VEGF expression (0.22±0.07, 0.41±0.08, 0.38±0.07ng/g). We found no significant d...Continue Reading


Oct 20, 2001·Journal of Korean Medical Science·J H HongJ H Park
Sep 9, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Oliver BaumIris Baumgartner
Jun 30, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A J DevanesanS Homer-Vanniasinkam
May 18, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Qiang TanWansong Yang
Jun 11, 2010·European Journal of Clinical Investigation·Himadri RoySeppo Ylä-Herttuala
Mar 2, 2011·Postȩpy higieny i medycyny doświadczalnej·Barbara Głowińska-OlszewskaArtur Bossowski
Mar 2, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ami R AminiSyam P Nukavarapu
Apr 27, 2012·Experimental Diabetes Research·Roberto BassiPaolo Fiorina
Apr 4, 2013·Journal of Diabetes Investigation·Aaron I VinikCarolina M Casellini
Jul 3, 2013·Journal of Diabetes and Its Complications·Cyrus V Desouza
Apr 20, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Kai-Hang Yiu, Hung-Fat Tse
Feb 20, 2012·Journal of Diabetes Investigation·Atsunori KashiwagiUNKNOWN Committee on the Standardization of Diabetes Mellitus‐Related Laboratory Testing of Japan Diabetes Society

❮ Previous
Next ❯


Feb 13, 2016·Journal of Biomedical Materials Research. Part a·Tongqiang ZouYubo Fan
Jul 14, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ying WangHua Yan
Oct 26, 2016·In Vitro Cellular & Developmental Biology. Animal·Phuc Van PhamNgoc Kim Phan
Feb 28, 2020·Experimental and Therapeutic Medicine·Wen ZengRong Ju

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia Cerebrovascular Disease

Basal ganglia cerebrovascular disease is a condition where the blood vessels in the basal ganglia are damaged or malfunction. Discover the latest research on basal ganglia cerebrovascular disease here.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.