Pro-angiogenic gene expression is associated with better outcome on sunitinib in metastatic clear-cell renal cell carcinoma

Acta Oncologica
B BeuselinckJessica Zucman-Rossi

Abstract

Clear-cell renal cell carcinomas (ccRCC) are characterized by hyper-vascularization and can respond to vascular endothelial growth factor receptor (VEGFR) inhibitors such as sunitinib. We aimed to study the predictive value of the expression of genes in the hypoxia induced factor (HIF) - vascular endothelial growth factor (VEGF) - VEGFR-pro-angiogenic pathway in metastatic ccRCC (m-ccRCC) patients treated with sunitinib and the correlation between the expression of these genes and the molecular ccrcc-classification, the expression of genes involved in the immune-suppressive microenvironment and Von Hippel-Lindau (VHL) - and Polybromo-1 (PBRM1) - mutational status. m-ccRCC patients treated with sunitinib as first-line targeted therapy were included. Gene expression was studied in the primary nephrectomy sample by qRT-PCR, VHL- and PBRM1-mutational status by sequencing. Response rate by RECIST, progression-free survival (PFS) and overall survival (OS) were study endpoints. One hundred and four patients were included. On multivariate-analysis, HIF2A-, platelet derived growth factor receptor beta (PDGFRB)-, VEGFC-, VEGFR1- and VEGFR2-expression were correlated with PFS and HIF1A-, HIF2A-, VEGFR1- and VEGFR2-expression with OS. VEGF...Continue Reading

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Citations

Jan 11, 2020·Frontiers in Oncology·Carmine D'AnielloGaetano Facchini
May 28, 2020·Journal of Clinical Medicine·Antonella ArgentieroNicola Silvestris
Aug 1, 2020·Nature Reviews. Nephrology·C Marcela Díaz-MonteroJames H Finke
Aug 1, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Laetitia MaugeUNKNOWN PREINSUT study group
May 12, 2019·IScience·Elizabeth G PorterEmily C Dykhuizen
Apr 4, 2021·International Journal of Molecular Sciences·Niki M ZachariasNeema Navai
Jun 24, 2019·Clinical Genitourinary Cancer·Annelies VerbiestBenoit Beuselinck

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