Brain-derived neurotrophic factor (BDNF) promotes the function and survival of the major neuronal types affected in Alzheimer disease, such as hippocampal, cortical and basal forebrain cholinergic neurons. We and others have demonstrated a reduction in BDNF mRNA expression in Alzheimer's disease hippocampus and cortex, which may help to explain the selective vulnerability of these neurons. Several studies have also shown decreased BDNF protein in Alzheimer's disease. BDNF protein is synthesized as a precursor, proBDNF, which is cleaved to the mature 14-kDa form. We demonstrate here that BDNF exists as a mixture of proBDNF and mature BDNF in all regions tested of human brain. Using Western blotting, we observe a 40% reduction in proBDNF levels in Alzheimer's disease parietal cortex compared to controls. Thus, decreased BDNF protein measured by ELISA and immunohistochemistry likely represents a mixture of the two BDNF forms, and previously reported decreases in BDNF protein may be due, at least in part, to a significant reduction in proBDNF levels. Although the biological activity of proBDNF is unknown, reduced proBDNF may have functional consequences for the selective neuronal degeneration in Alzheimer's disease brain.
Increase of BDNF serum concentration during donepezil treatment of patients with early Alzheimer's disease
Peripheral immune activation by lipopolysaccharide decreases neurotrophins in the cortex and hippocampus in rats
Allowing animals to bite reverses the effects of immobilization stress on hippocampal neurotrophin expression
Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance
Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain
Multiple effects of physical activity on molecular and cognitive signs of brain aging: can exercise slow neurodegeneration and delay Alzheimer's disease?
BDNF polymorphism predicts the rate of decline in skilled task performance and hippocampal volume in healthy individuals
Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice
Effect of aging on brain-derived neurotrophic factor, proBDNF, and their receptors in the hippocampus of Lou/C rats
CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease
Spatial navigation in complex and radial mazes in APP23 animals and neurotrophin signaling as a biological marker of early impairment
The brain-derived neurotrophic factor gene as a possible susceptibility candidate for Alzheimer's disease in a chinese population
Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan
Acute stress alters transcript expression pattern and reduces processing of proBDNF to mature BDNF in Dicentrarchus labrax
The differences in neuroprotective efficacy of progesterone and medroxyprogesterone acetate correlate with their effects on brain-derived neurotrophic factor expression
Mature and precursor brain-derived neurotrophic factor have individual roles in the mouse olfactory bulb
Molecular mechanisms of environmental enrichment: impairments in Akt/GSK3β, neurotrophin-3 and CREB signaling
The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease
Impact of acute aerobic exercise and cardiorespiratory fitness on visuospatial attention performance and serum BDNF levels
The effect of neuropeptide Y on cell survival and neurotrophin expression in in-vitro models of Alzheimer's disease
Roles of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) signalling in Alzheimer's disease
Commentary: Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT2A levels
Status epilepticus induces a TrkB to p75 neurotrophin receptor switch and increases brain-derived neurotrophic factor interaction with p75 neurotrophin receptor: an initial event in neuronal injury induction
Brain-derived neurotrophic factor (BDNF)-like immunoreactivity localization in the retina and brain of Cichlasoma dimerus (Teleostei, Perciformes)
Spatial memory training modifies the expression of brain-derived neurotrophic factor tyrosine kinase receptors in young and aged rats
Brain-derived neurotrophic factor and TrkB expression in the "oldest-old," the 90+ Study: correlation with cognitive status and levels of soluble amyloid-beta
Brain-derived neurotrophic factor facilitates TrkB down-regulation and neuronal injury after status epilepticus in the rat hippocampus
BDNF and the diseased nervous system: a delicate balance between adaptive and pathological processes of gene regulation
Brain-derived neurotrophic factor signaling is altered in the forebrain of Engrailed-2 knockout mice
Soluble beta amyloid(1-42): a critical player in producing behavioural and biochemical changes evoking depressive-related state?
Is the pattern of nerve cell loss in aging and Alzheimer's disease a real, or only an apparent, selectivity?
Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture
Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: lesion effects in the rat brain and levels in Alzheimer's disease
Differential regulation of brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer's disease
Nerve growth factor mRNA and protein levels measured in the same tissue from normal and Alzheimer's disease parietal cortex
The pro-protein convertase PC1 is induced in the transected sciatic nerve and is present in cultured Schwann cells: comparison with PC5, furin and PC7, implication in pro-BDNF processing
BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies
Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor
The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor
Basal Forebrain- Circuits
Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.
Basal Forebrain & Food Avoidance
Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.