Pro-healing potential of hemin: an inducer of heme oxygenase-1

European Journal of Pharmacology
Azad Ahmad AhangerJitendra K Malik

Abstract

Hemin induces heme oxygenase (HO), an enzyme which degrades heme in a rate-limiting manner and has an important role in cellular protection against oxidative stress and apoptosis. This HO inducer may be of potential therapeutic value in wound healing and inflammation. To identify the beneficial activity of HO vis a vis wound healing, hemin was used as inducer of HO in rats using a full-thickness cutaneous wound model. Hemin treatment increased cellular proliferation and collagen synthesis as evidenced by increase in wound contraction and hydroxyproline and glucosamine contents. mRNA expression of cytokines endorsed fast healing as was indicated by inhibition of pro-inflammatory cytokines such as ICAM-1 and TNF-alpha and up-regulation of anti-inflammatory cytokine IL-10.

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Citations

May 18, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Azad Ahmad AhangerDinesh Kumar
Nov 26, 2015·Brain Injury : [BI]·Hao ChenGuiyun Cui
Jun 21, 2014·International Wound Journal·Azad A AhangerDinesh Kumar
Sep 17, 2014·Journal of Cellular and Molecular Medicine·Ditte M S LundvigFrank A D T G Wagener
Sep 9, 2015·Molecular and Cellular Biochemistry·Sung-Ho KookJeong-Chae Lee
Feb 22, 2017·International Journal of Molecular Sciences·Niels A J CremersFrank A D T G Wagener
Jul 6, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Dhirendra KumarDinesh Kumar
Sep 21, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Lucas Fernando Sérgio GushikenCláudia Helena Pellizzon
Nov 11, 2017·Complementary Therapies in Clinical Practice·Duane T Lowe
Oct 11, 2021·Veterinary Medicine and Science·Lei HuangKejiao Jiang

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