Pro-inflammatory Actions of Heme and Other Hemoglobin-Derived DAMPs.

Frontiers in Immunology
Marcelo T Bozza, Viktória Jeney

Abstract

Damage associated molecular patterns (DAMPs) are endogenous molecules originate from damaged cells and tissues with the ability to trigger and/or modify innate immune responses. Upon hemolysis hemoglobin (Hb) is released from red blood cells (RBCs) to the circulation and give a rise to the production of different Hb redox states and heme which can act as DAMPs. Heme is the best characterized Hb-derived DAMP that targets different immune and non-immune cells. Heme is a chemoattractant, activates the complement system, modulates host defense mechanisms through the activation of innate immune receptors and the heme oxygenase-1/ferritin system, and induces innate immune memory. The contribution of oxidized Hb forms is much less studied, but some evidence show that these species might play distinct roles in intravascular hemolysis-associated pathologies independently of heme release. This review aims to summarize our current knowledge about the formation and pro-inflammatory actions of heme and other Hb-derived DAMPs.

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Citations

Oct 11, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elisa B PrestesMarcelo T Bozza
Nov 5, 2020·Journal of Food Biochemistry·Hassan S AlamriMohammad A Alfhili
Jan 13, 2021·Biological & Pharmaceutical Bulletin·Maaged AkielMohammad A Alfhili
Apr 1, 2021·Cellular and Molecular Life Sciences : CMLS·Agata SzadeAlicja Józkowicz
Apr 14, 2021·Biochemical and Biophysical Research Communications·Toria TomasekJamie E Meegan
Apr 27, 2021·Frontiers in Immunology·Zahra KargarpourReinhard Gruber
Jun 1, 2021·Frontiers in Immunology·Marc PfefferléFlorence Vallelian
Jul 26, 2021·Free Radical Biology & Medicine·Rafael Cardoso Maciel Costa SilvaMarcelo Torres Bozza
Jul 21, 2021·International Journal of Molecular Sciences·Filomena LongoAntonio Piga
Aug 8, 2021·International Journal of Molecular Sciences·József Balla, Abolfazl Zarjou
Aug 13, 2021·Wiener medizinische Wochenschrift·Anton TkachenkoOksana Nakonechna

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Methods Mentioned

BETA
acetylation
nucleotide exchange

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