PMID: 11341374May 9, 2001Paper

Pro-inflammatory activity of contaminating DNA in hyaluronic acid preparations

The Journal of Pharmacy and Pharmacology
M C Filion, N C Phillips

Abstract

Hyaluronic acid (HA), an abundant non-sulfated glycosaminoglycan component of the extracellular matrix, has applications in drug delivery, tissue engineering and as an ingredient in cosmetics. HA preparations containing high-molecular-weight polymers are also used in the treatment of inflammatory disorders such as arthritis and interstitial cystitis. Low-molecular-weight fragments derived from HA have been reported to induce pro-inflammatory cytokines such as IL-12 and TNF-alpha, and could therefore potentially exacerbate existing inflammation. We therefore examined the pro-inflammatory activity of HA preparations, since inflammatory reactions are known to occur following administration of HA. We tested low-molecular-weight fragments obtained from seven different HA preparations, either by sonication (approximately equals 3 x 10(5) Da) or by hyaluronidase digestion (approximately equals 1 x 10(4) Da), for the ability to induce the synthesis of IL-12 and TNF-alpha by human monocytic cells. We found that two of the seven HA preparations tested stimulated the synthesis of IL-12 and TNF-alpha by human monocytic cells. We unexpectedly found that the induction of IL-12 and TNF-alpha by these HA preparations was not due to their degra...Continue Reading

References

May 1, 1977·Analytical Biochemistry·J J Sedmak, S E Grossberg
Mar 1, 1992·Clinical and Experimental Immunology·T J Christmas, G F Bottazzo
Jul 1, 1987·Arthritis and Rheumatism·R L Goldberg, B P Toole
Nov 1, 1985·Annals of the Rheumatic Diseases·J D McNeilL G Cleland
Apr 6, 1995·Nature·A M KriegD M Klinman
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·D M KlinmanA M Krieg
Jul 1, 1996·The Journal of Urology·A MoralesM Lundie
Feb 1, 1996·Trends in Microbiology·A M Krieg
Apr 1, 1993·Osteoarthritis and Cartilage·J G Peyron
Nov 15, 1996·The Journal of Clinical Investigation·A Aruffo
Mar 27, 1997·Nature·T SparwasserH Wagner
Jul 1, 1997·The Journal of Clinical Investigation·D A SchwartzA M Krieg
Jul 1, 1997·Journal of Internal Medicine·A Engström-Laurent
Jan 16, 1998·Baillière's Clinical Rheumatology·J R Kirwan, E Rankin
Sep 29, 1998·The Journal of Urology·D R EricksonV P Bhavanandan
Oct 2, 1998·Advances in Immunology·G Trinchieri
Mar 20, 1999·Immunobiology·D C NeujahrD S Pisetsky
Apr 29, 1999·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·H MatsunoT Kimura

❮ Previous
Next ❯

Citations

Feb 6, 2002·Matrix Biology : Journal of the International Society for Matrix Biology·Paul W Noble
Mar 21, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jaume Alijotas-ReigMiquel Vilardell-Tarrés
Nov 30, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jaume Alijotas-ReigMiquel Vilardell-Tarrés
Apr 26, 2003·American Journal of Respiratory and Critical Care Medicine·Gerard M Turino, Jerome O Cantor
May 10, 2003·American Journal of Respiratory Cell and Molecular Biology·Marcella M MascarenhasDeborah A Quinn
Aug 12, 2008·Critical Care : the Official Journal of the Critical Care Forum·Yung-Yang LiuDeborah A Quinn
May 27, 2014·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·John-Max MongkhonMohamed Benderdour
Dec 21, 2010·Journal of the American Academy of Dermatology·Luis RequenaLorenzo Cerroni
Mar 26, 2010·Journal of Biomedical Materials Research. Part a·Daniel B LyleJohn J Langone
Aug 1, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·L H BookbinderG I Frost
Jun 23, 2015·Seminars in Arthritis and Rheumatism·Yves HenrotinAlberto Migliore
Aug 6, 2009·International Journal of Toxicology·Lillian C BeckerF Alan Andersen
Jan 24, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·J Alijotas-Reig, V Garcia-Gimenez
Nov 22, 2001·The Journal of Biological Chemistry·Markku I TammiEva A Turley
Nov 22, 2001·The Journal of Biological Chemistry·Eva A TurleyLilly Y W Bourguignon
Mar 28, 2013·Journal of Biomedical Materials Research. Part a·Larissa F BaevaMarilyn M Lightfoote
Jul 19, 2017·Journal of Cosmetic Dermatology·Carlos Eduardo P AlcântaraRicardo A Mesquita
Oct 25, 2017·Frontiers in Oncology·Lena BohaumilitzkyHeike Boehm
Nov 28, 2019·Journal of Veterinary Science·Henrique M NeuenschwanderRaquel Y A Baccarin
Apr 3, 2012·Journal of Carbohydrate Chemistry·Zhaojun Yin, Xuefei Huang
Jul 11, 2006·European Journal of Cell Biology·Robert SternKazuki N Sugahara

❮ Previous
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