Pro-inflammatory State in Monoclonal Gammopathy of Undetermined Significance and in Multiple Myeloma Is Characterized by Low Sialylation of Pathogen-Specific and Other Monoclonal Immunoglobulins

Frontiers in Immunology
Adrien BosseboeufJean Harb

Abstract

Multiple myeloma (MM) and its pre-cancerous stage monoclonal gammopathy of undetermined significance (MGUS) allow to study immune responses and the chronology of inflammation in the context of blood malignancies. Both diseases are characterized by the production of a monoclonal immunoglobulin (mc Ig) which for subsets of MGUS and MM patients targets pathogens known to cause latent infection, a major cause of inflammation. Inflammation may influence the structure of both polyclonal (pc) Ig and mc Ig produced by malignant plasma cells via the sialylation of Ig Fc fragment. Here, we characterized the sialylation of purified mc and pc IgGs from 148 MGUS and MM patients, in comparison to pc IgGs from 46 healthy volunteers. The inflammatory state of patients was assessed by the quantification in serum of 40 inflammation-linked cytokines, using Luminex technology. While pc IgGs from MGUS and MM patients showed heterogeneity in sialylation level, mc IgGs from both MGUS and MM patients exhibited a very low level of sialylation. Furthermore, mc IgGs from MM patients were less sialylated than mc IgGs from MGUS patients (p < 0.01), and mc IgGs found to target an infectious pathogen showed a lower level of sialylation than mc IgGs of undete...Continue Reading

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Citations

Jun 13, 2019·International Journal of Molecular Sciences·Alessandro AllegraSebastiano Gangemi
Jun 27, 2020·Mediators of Inflammation·Paweł RobakTadeusz Robak
Jun 17, 2020·Frontiers in Immunology·Adrien BosseboeufSylvie Hermouet
Jun 24, 2020·Blood·Marita WesthrinTherese Standal
Apr 1, 2021·Clinical Lymphoma, Myeloma & Leukemia·Matteo CoenJacques Serratrice
Jun 2, 2021·Cancer Immunology, Immunotherapy : CII·Morten N AndersenHolger J Møller
Aug 28, 2021·International Journal of Molecular Sciences·Giuseppe MurdacaSebastiano Gangemi

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Methods Mentioned

BETA
glycosylation
electrophoresis
enzyme-linked immunosorbent assay
ELISA
Sialylation

Software Mentioned

GenePix ® Pro 4 Microarray Acquisition

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