Pro-nociceptive and anti-nociceptive effects of a conditioned pain modulation protocol in participants with chronic low back pain and healthy control subjects

Manual Therapy
Martin RabeyHelen Slater

Abstract

People with chronic pain may exhibit pro-nociceptive phenotypes characterised partly by reduced conditioned pain modulation (CPM). Characterising variability in CPM in people with chronic low back pain (CLBP) may inform management. To investigate pro/anti-nociceptive effects of a CPM protocol in age/sex-matched healthy controls (HCs) and people with CLBP. Case-controlled trial (64 participants/group). The CPM protocol involved: test stimulus (TS) (noxious pressure applied by algometer to lumbar region); conditioning stimulus (CS) (noxious heat applied by thermode to dorsal hand). CPM recruitment was measured by the change in pain intensity (rated on a numeric rating scale (NRS)) of the TS in the presence and absence of the CS. Responses to this CPM protocol were variable for both groups with measures consistent with either inhibitory or facilitatory effects. A significantly greater proportion of facilitatory responses were seen in the CLBP cohort compared to HCs (73% versus 31%). In response to the CS, participants with CLBP demonstrated a mean increase in NRS scores (mean 1.3 points; p < 0.001), while HCs did not (mean -0.2 points; p = 0.35) and the between-group difference in change scores was significant (mean 1.4 points; p ...Continue Reading

References

Mar 15, 1986·British Medical Journal·M J Gardner, D G Altman
Sep 24, 1999·Pain·Ronald Dubner, Ke Ren
Feb 19, 2003·Brain Research. Brain Research Reviews·Daniel Le Bars
May 3, 2005·Neuroscience Letters·Dorit PudDavid Yarnitsky
Jun 28, 2005·European Journal of Pain : EJP·André Farasyn, Romain Meeusen
Nov 22, 2007·Experimental Brain Research·Irit Weissman-FogelDorit Pud
Dec 17, 2008·The Spine Journal : Official Journal of the North American Spine Society·Eugene K WaiSimon Dagenais
Jan 16, 2010·The Journal of Pain : Official Journal of the American Pain Society·Gerrit van Wijk, Dieuwke S Veldhuijzen
Jan 29, 2010·Journal of Visualized Experiments : JoVE·Ruth LandauAlex Cahana
Mar 17, 2010·European Journal of Pain : EJP·David YarnitskyOliver Wilder-Smith
Apr 27, 2010·Pain·Lars Arendt-NielsenThomas Graven-Nielsen
May 28, 2010·Journal of Pain & Palliative Care Pharmacotherapy·Oliver Hamilton Wilder-SmithLars Arendt-Nielsen
Feb 11, 2011·Pain·Amanda M HallMichael K Nicholas
Apr 14, 2011·The Clinical Journal of Pain·Klaus BlumenstielRolf-Detlef Treede
Apr 23, 2011·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Søren O'NeillLars Arendt-Nielsen
Sep 18, 2012·The Journal of Pain : Official Journal of the American Pain Society·Gwyn N LewisPeter J McNair
Dec 25, 2012·The Journal of Pain : Official Journal of the American Pain Society·Stéphanie CormierPierre Rainville
Oct 15, 2013·The Clinical Journal of Pain·Søren O'NeillLars Arendt-Nielsen
Nov 26, 2013·Pain·David YarnitskyYelena Granovsky
Apr 5, 2014·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Richard A Armstrong

❮ Previous
Next ❯

Citations

Nov 26, 2019·The Clinical Journal of Pain·Y V Raghava NeelapalaLaura Frey-Law
Jul 22, 2020·Scandinavian Journal of Pain·Lars Arendt-NielsenPascal Madeleine
May 23, 2020·Pain Reports·Tibor M SzikszayKerstin Luedtke
Nov 7, 2017·European Journal of Pain : EJP·L Arendt-NielsenA Mohr Drewes
Aug 28, 2016·Experimental Brain Research·Claudia Horn-HofmannStefan Lautenbacher
Sep 6, 2017·The Clinical Journal of Pain·Martin RabeyPeter O'Sullivan
Aug 21, 2020·The Clinical Journal of Pain·Kasper S ChristensenThorvaldur S Palsson
Feb 10, 2020·The Journal of Pain : Official Journal of the American Pain Society·John D MarkmanRoger Chou
Dec 19, 2020·Neurophysiologie clinique = Clinical neurophysiology·Shankar Ramaswamy, Theresa Wodehouse
Jul 27, 2021·Neurophysiologie clinique = Clinical neurophysiology·Milena KovacevicAleksandar Knezevic
May 15, 2021·European Journal of Pain : EJP·Thorvaldur S PalssonThomas Graven-Nielsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.