Pro-oxidative effect of alpha-tocopherol in the oxidation of LDL isolated from co-antioxidant-depleted non-diabetic hemodialysis patients

Atherosclerosis
Sakae OhkawaHiromichi Kumagai

Abstract

The association between the antioxidants in LDL and the oxidizability of LDL assessed by the oxidation lag time during copper ion-catalyzed oxidation was investigated in 69 non-diabetic hemodialysis patients and 23 healthy volunteers. The concentrations of co-antioxidants, including ubiquinol-10, lycopene and beta-carotene, in LDL were significantly lower in the hemodialysis patients than in the healthy volunteers, while there was no difference in the alpha-tocopherol concentration between the groups. The lag time showed a significantly positive correlation with the alpha-tocopherol level (r = 0.62, P < 0.01) in the healthy subjects, but a significantly negative correlation (r = -0.38, P < 0.05) in the hemodialysis patients. Furthermore, in vitro incubation of LDL with alpha-tocopherol prolonged the lag time in the healthy subjects, but shortened it in the hemodialysis patients. These results suggested that the alpha-tocopherol might exert the pro-oxidative effect in co-antioxidant-depleted LDL that was isolated from the hemodialysis patients. Despite such co-antioxidant depletion and the pro-oxidative effect of alpha-tocopherol, the lag time in the hemodialysis patients was not statistically different from that in the healthy ...Continue Reading

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Citations

Oct 7, 2011·Kidney International·Jeff S Coombes, Robert G Fassett
Jan 16, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Lorenzo IughettiFiorella Balli
Nov 29, 2005·Clinical Biochemistry·Aleksandra JurekAndrzej Klein
Jul 13, 2005·Advances in Chronic Kidney Disease·Mariana S Markell
Mar 17, 2007·Renal Failure·Georgia AntoniadiVassilis Vargemezis

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