PMID: 9185698Jun 11, 1997Paper

Pro-protein convertase gene expression in human breast cancer

International Journal of Cancer. Journal International Du Cancer
M ChengR P Shiu

Abstract

As a first step towards elucidating the role that pro-protein convertases play in the growth regulation of breast cancer, we studied the gene expression of 6 known human convertase members (PC1/PC3, PC2, furin/PACE, PACE4, PC5/PC6 and PC7/LPC) in human breast cancer tumors and cell lines. PC1, furin, PACE4 and PC7 mRNAs were detected by reverse transcriptase-polymerase chain reaction (RT-PCR) amplification in all 7 human breast cancer cell lines and 30 breast tumor tissues tested. PC5 expression was detected in 2/30 tumor tissues. PC2 mRNA, however, was not detected. In situ hybridization localized furin mRNA to the tumor cells; adjacent fibrous stroma and blood vessel elements were negative for furin gene expression. Thirty breast tumors with varying quantities of estrogen and progesterone receptors were assayed for furin, PACE4 and PC1 mRNAs by quantitative RT-PCR, and 22 tumors were assayed for PC7 mRNA. An apparent association was observed only between PACE4 and estrogen receptors. No statistically significant correlation was found between the levels of steroid receptors and the expression of human furin, PCI and PC7 genes. Convertase mRNA levels appeared similar in both the estrogen-responsive and -unresponsive breast canc...Continue Reading

References

Dec 1, 1990·The Journal of Cell Biology·P A BresnahanG Thomas
Dec 1, 1987·The Journal of Clinical Investigation·J A SchalkenW J Van de Ven
Jan 1, 1988·Cancer Treatment and Research·R B Dickson, M E Lippman
Jan 1, 1973·The Journal of Clinical Investigation·W L McGuire
May 5, 1995·The Journal of Biological Chemistry·C M DuboisR Leduc
May 31, 1993·Annals of the New York Academy of Sciences·M MbikayM Chretien
Mar 1, 1996·Nature Genetics·P S Steeg
Mar 1, 1996·Nature Genetics·R A JensenJ T Holt
Mar 15, 1996·The Biochemical Journal·A BruzzanitiM T Gillespie

❮ Previous
Next ❯

Citations

Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·D E BassiA J Klein-Szanto
Jan 7, 2010·Canadian Journal of Physiology and Pharmacology·Anne BlanchardRobert P C Shiu
Oct 3, 2002·Nature Reviews. Molecular Cell Biology·Gary Thomas
Jun 13, 2009·The Journal of Biological Chemistry·Renhong Tang, Steven D Rosen
Aug 1, 2009·Bioconjugate Chemistry·Anca Dragulescu-AndrasiJianghong Rao
Aug 28, 2012·The Biochemical Journal·Jingjing ZhuJohn W M Creemers
Jan 8, 2015·Expert Opinion on Therapeutic Patents·Frédéric CoutureRobert Day
Dec 30, 2011·The New England Journal of Medicine·Andrew W Artenstein, Steven M Opal
Apr 4, 2017·International Journal of Cancer. Journal International Du Cancer·Patricia Jaaks, Michele Bernasconi
Jun 3, 2011·Translational Oncology·François D'AnjouRobert Day
Jan 5, 2002·International Journal of Cancer. Journal International Du Cancer·Anne Hansen ReeØystein Fodstad
Jan 27, 2000·The Journal of Trauma·T NishimuraA A Meyer
Feb 15, 2003·FEBS Letters·Horst PosthausEliane Müller
Sep 6, 2001·Molecular Carcinogenesis·D E BassiA J Klein-Szanto
Jun 11, 2003·The Journal of Gene Medicine·A Gómez-TreviñoE Mercadé
Dec 20, 2011·Endocrine-related Cancer·Gavin P VinsonJohn R Puddefoot
Oct 12, 2018·Chembiochem : a European Journal of Chemical Biology·Haolun CheongBengang Xing
Jun 9, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Joanna G KochGuillermina Lozano
Jul 27, 2007·Breast Cancer Research and Treatment·Nalin SiriwardhanaHwa-Chain Robert Wang
Sep 17, 2005·Molecular Carcinogenesis·Daniel E BassiAndres J P Klein-Szanto
Aug 20, 2005·The Journal of Biological Chemistry·Weijun JinDaniel J Rader
Apr 19, 2007·Molecular Carcinogenesis·Ricardo López de CiccoAndrés J P Klein-Szanto
Jan 24, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bradley K McCollMarc G Achen
May 27, 2010·The Journal of Clinical Endocrinology and Metabolism·Kazumi IinoHirotoshi Nakamura
Oct 16, 2012·Molecular Carcinogenesis·Kelly A Brant, George D Leikauf
Jul 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Neil A TaylorJohn W M Creemers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.