Pro: Risk scores for chronic kidney disease progression are robust, powerful and ready for implementation

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Navdeep TangriPaul Komenda

Abstract

Accurate risk prediction for chronic kidney disease (CKD) progression can inform the patient-provider dialogue, and provide actionable thresholds for key clinical decisions. In 2011, we developed the kidney failure risk equations (KFREs) to predict the risk of kidney failure requiring dialysis or transplant in patients with CKD. Subsequently, the KFREs have been extensively validated, and have now been proven accurate in multiple continents, ethnicities and disease-specific subpopulations. They can discriminate progressors from non-progressors, and are well calibrated and easy to use. We believe that current and future studies should now focus on clinical implementation of the KFREs, through quality improvement initiatives and cluster randomized trials. A risk-based care paradigm for CKD care can be achieved through knowledge translation and implementation research.

References

Jun 17, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Waqar H KazmiAnnamaria T Kausz
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
May 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·David CollisterPaul Komenda
Apr 13, 2011·JAMA : the Journal of the American Medical Association·Navdeep TangriAndrew S Levey
Aug 16, 2011·Lancet·Andrew S Levey, Josef Coresh
Oct 9, 2012·Current Opinion in Nephrology and Hypertension·Claudio RigattoNavdeep Tangri
Apr 17, 2013·Annals of Internal Medicine·Navdeep TangriAndrew S Levey
Jul 27, 2014·Journal of the American Society of Nephrology : JASN·David A DrewDaniel E Weiner
Dec 18, 2014·Journal of the American Geriatrics Society·Shayan ShirazianJoseph Mattana
Jan 13, 2016·JAMA : the Journal of the American Medical Association·Navdeep TangriUNKNOWN CKD Prognosis Consortium
Jun 22, 2016·Advances in Chronic Kidney Disease·Peter WojciechowskiPaul Komenda

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Citations

Mar 13, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marie Evans, Kai Lopau
Apr 11, 2018·Canadian Journal of Kidney Health and Disease·Michelle D SmekalBrenda R Hemmelgarn
Sep 30, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rémi KaboréKaren Leffondré
Oct 17, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Simon SawhneyAdeera Levin
Mar 10, 2021·Journal of the American Society of Nephrology : JASN·Chava L RamspekUNKNOWN EQUAL Study Investigators
May 8, 2021·Journal of the American Society of Nephrology : JASN·Vishal DuggalManjula Kurella Tamura

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