Pro-thyrotropin-releasing hormone concentrations in the brain of ataxic mice

Journal of the Neurological Sciences
T MitsumaK Ando

Abstract

Concentrations of pro-thyrotropin-releasing hormone (pro-TRH) were studied in the brain of the Weaver ataxic mouse, the Purkinje cell degenerative mouse (pcd-ataxic mouse), the Staggerer ataxic mouse and the C3H mouse. The brain tissue was dissected into 7 parts, e.g., hypothalamus, cerebrum, thalamus, striatum, brain stem, cerebellum and cervical spinal cord. Pro-TRH concentrations in each part of the brain were measured by radioimmunoassay. Pro-TRH concentrations in the brain of Weaver ataxic mice, pcd-ataxic mice and Staggerer ataxic mice were significantly higher in the thalamus, brain stem, cerebellum and cervical spinal cord. Pro-TRH concentrations in the hypothalamus, striatum and cerebrum of ataxic mice did not differ from those of controls. The elution profile of acetic acid extracted cerebellum of ataxic mice on Sephadex G-50 was identical to that of synthetic pro-TRH. These findings suggest that changes in pro-TRH concentrations in the brain may play a pathophysiological role in ataxic mice.

References

Jan 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·R J MullenR L Sidman
Apr 1, 1989·Experimental and Clinical Endocrinology·T MitsumaY Senda
Sep 1, 1986·Journal of the Neurological Sciences·T MitsumaK Ando
Jan 21, 1982·The New England Journal of Medicine·I M Jackson

❮ Previous
Next ❯

Citations

Jan 1, 1995·European Archives of Psychiatry and Clinical Neuroscience·P DiószeghyF Mechler
Mar 25, 2006·Bulletin of Entomological Research·J T MargaritopoulosR L Blackman
Oct 1, 1995·Evolution; International Journal of Organic Evolution·Douglas J FutuymaDaniel J Funk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.