Proactive Motor Functional Recovery Following Immersive Virtual Reality-Based Limb Mirroring Therapy in Patients with Subacute Stroke.

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Destaw B MekbibDongrong Xu

Abstract

Virtual reality (VR) is considered to be a promising therapeutic technology for the rehabilitation of upper extremities (UEs) post-stroke. Recently, we designed and then implemented a neuroscientifically grounded VR protocol for the rehabilitation of patients with stroke. The system provides unilateral and bilateral limb mirroring exercises in a fully immersive virtual environment that may stimulate and activate the mirror neuron system in the brain to help patients for their rehabilitation. Twelve patients with subacute stroke underwent the newly implemented VR treatment in addition to conventional rehabilitation for 8 consecutive weekdays. The treatment effect on brain reorganization and motor function was investigated using resting-state fMRI (rs-fMRI) and the Fugl-Meyer assessment for Upper Extremity (FM-UE), respectively. Fifteen healthy controls (HCs) also underwent rs-fMRI scanning one time. The study finally obtained usable data from 8 patients and 13 HCs. After the intervention, patients demonstrated significant improvement in their FM-UE scores (p values < 0.042). Voxel-wise functional connectivity (FC) analysis based on the rs-fMRI data found that HCs showed widespread bilateral FC patterns associated with the domina...Continue Reading

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Citations

Jan 15, 2021·Annals of the New York Academy of Sciences·Destaw B MekbibDongrong Xu
Apr 6, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaowei SunTiansong Yang
Aug 6, 2021·Archives of Physical Medicine and Rehabilitation·Jie HaoKa-Chun Siu

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