PMID: 11311728Apr 20, 2001Paper

Proadrenomedullin N-terminal 20 peptide (PAMP) inhibits food intake and gastric emptying in mice

Peptides
K OhinataMasaaki Yoshikawa

Abstract

We found that proadrenomedullin N-terminal 20 peptide (PAMP) decreased dose-dependently (3-30 nmol/mouse) food intake after intra-third cerebroventricular administration in fasted ddY mice. Gastric emptying also was delayed after central injection of PAMP. In our previous study, PAMP was demonstrated to elicit hyperglycemia via bombesin (BN) receptor. Then, we examined whether the effects of PAMP on feeding and gastric emptying were induced through BN receptor. Surprisingly, PAMP-induced reductions in feeding and gastric emptying rate were not blocked by a BN antagonist, [D-Phe(6), Leu-NHEt(13), des-Met(14)]-BN (6-14). PAMP suppressed feeding in mice lacking gastrin-releasing peptide receptor or BN receptor subtype-3. These results indicate that centrally administered PAMP inhibits food intake, involving the delayed gastric emptying, not through BN receptors but through selective PAMP receptor.

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Citations

Jan 5, 2002·Peptides·K OhinataM Yoshikawa
Jan 30, 2002·Peptides·Kousaku OhinataMasaaki Yoshikawa
Jul 6, 2010·Neuroscience Letters·Eun Ran Kim, Tooru M Mizuno
Sep 26, 2006·Prostaglandins & Other Lipid Mediators·Kousaku OhinataMasaaki Yoshikawa
May 22, 2003·Progress in Histochemistry and Cytochemistry·Luis M MontuengaAna C Villaro

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