PMID: 9449234Feb 4, 1998Paper

Proadrenomedullin N-terminal 20-peptide (PAMP) receptors and signal transduction in the rat adrenal gland

Life Sciences
J P HinsonS Kapas

Abstract

Using ligand binding techniques we have demonstrated specific saturable binding of proadrenomedullin N-terminal 20-peptide (PAMP) in the rat adrenal zona glomerulosa. Hill plot analysis revealed two classes of receptor (Kd1 1.9nmol/l Bmax 53fmol/mg protein: Kd2 10nmol/l, Bmax 225fmol/mg). [125 I]-PAMP was displaced by adrenomedullin at one of these receptors. In the adrenal medulla [125 I]-PAMP bound to a single class of specific receptor (Kd 4.9 nmol/l: Bmax 556fmol/mg). PAMP caused an increase in cAMP generation by zona glomerulosa cells, but not inner zone/medulla cells. These data suggest that PAMP acts through a specific receptor to elevate cAMP levels in the rat adrenal.

References

Jun 1, 1987·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·N Gallo-PayetH Isler
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard

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Citations

Dec 10, 1999·Regulatory Peptides·H C ChampionP J Kadowitz
Sep 12, 2000·Current Hypertension Reports·J D Greifenkamp, D J DiPette
Apr 13, 2005·Biochemical and Biophysical Research Communications·Masazumi KamoharaMasao Katou
Jun 2, 2005·European Journal of Medicinal Chemistry·Miguel JuliánFrank Cuttitta

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