Proanthocyanidins: Components, Pharmacokinetics and Biomedical Properties

The American Journal of Chinese Medicine
Yan-Xi ZengYi-Han Chen

Abstract

Proanthocyanidins (PAs) are a group of polyphenols enriched in plant and human food. In recent decades, epidemiological studies have upheld the direct relationship between PA consumption and health benefits; therefore, studies on PAs have become a research hotspot. Although the oral bioavailability of PAs is quite low, pharmacokinetics data revealed that some small molecules and colonic microbial metabolites of PAs could be absorbed and exert their health beneficial effects. The pharmacological effects of PAs mainly include anti-oxidant, anticancer, anti-inflammation, antimicrobial, cardiovascular protection, neuroprotection, and metabolism-regulation behaviors. Moreover, current toxicological studies show that PAs have no observable toxicity to humans. This review summarizes the resources, extraction, structures, pharmacokinetics, pharmacology, and toxicology of PAs and discusses the limitations of current studies. Areas for further research are also proposed.

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Citations

Feb 2, 2021·Journal of Agricultural and Food Chemistry·Zhenyu WangZhiyong He
Dec 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tsz Ki WangYunjian Zhang
Feb 25, 2021·The American Journal of Chinese Medicine·Xiao LiHaixue Kuang
Apr 9, 2021·The American Journal of Chinese Medicine·Hui ZhaoHaibo Xu

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