Proanthocyanidins from the American Cranberry (Vaccinium macrocarpon) inhibit matrix metalloproteinase-2 and matrix metalloproteinase-9 activity in human prostate cancer cells via alterations in multiple cellular signalling pathways

Journal of Cellular Biochemistry
Bob A DézielRobert A R Hurta

Abstract

Prostate cancer is one of the most common cancers in the Western world, and it is believed that an individual's diet affects his risk of developing cancer. There has been an interest in examining phytochemicals, the secondary metabolites of plants, in order to determine their potential anti-cancer activities in vitro and in vivo. In this study we document the effects of proanthocyanidins (PACs) from the American Cranberry (Vaccinium macrocarpon) on matrix metalloproteinase (MMP) activity in DU145 human prostate cancer cells. Cranberry PACs decreased cellular viability of DU145 cells at a concentration of 25 µg/ml by 30% after 6 h of treatment. Treatment of DU145 cells with PACs resulted in an inhibition of both MMPs 2 and 9 activity. PACs increased the expression of TIMP-2, a known inhibitor of MMP activity, and decreased the expression of EMMPRIN, an inducer of MMP expression. PACs decreased the expression of PI-3 kinase and AKT proteins, and increased the phosphorylation of both p38 and ERK1/2. Cranberry PACs also decreased the translocation of the NF-κB p65 protein to the nucleus. Cranberry PACs increased c-jun and decreased c-fos protein levels. These results suggest that cranberry PACs decreases MMP activity through the in...Continue Reading

References

Nov 1, 1991·Cancer Causes & Control : CCC·K A Steinmetz, J D Potter
Feb 14, 1998·International Journal of Cancer. Journal International Du Cancer·P ValenteA Albini
Jan 6, 2000·Journal of the National Cancer Institute·J H CohenJ L Stanford
Jun 3, 2000·Human Pathology·L BubendorfM J Mihatsch
Oct 6, 2000·Genes & Development·C Abate-Shen, M M Shen
Jan 5, 2002·Journal of the National Cancer Institute·Jeffrey A NemethMichael L Cher
Nov 6, 2003·Clinical Orthopaedics and Related Research·Valentine B AndelaRegis J O'Keefe
Mar 5, 2004·Journal of the National Cancer Institute·Michael Smith
Oct 19, 2004·Planta medica·Christina Ende, Rolf Gebhardt
May 24, 2005·Biochimica Et Biophysica Acta·Mikael Björklund, Erkki Koivunen
Oct 20, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Michael D MatchettRobert A R Hurta
May 3, 2006·Biological & Pharmaceutical Bulletin·Eun-Rhan WooKeon Wook Kang
May 25, 2006·International Journal of Cancer. Journal International Du Cancer·Sabine RiethdorfKlaus Pantel
Sep 16, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Antonio Z Gimeno-GarcíaEnrique Quintero
Dec 21, 2006·Nutrition and Cancer·Peter J FergusonJames Koropatnick
Dec 22, 2006·The Journal of Nutrition·Catherine C Neto
Jul 10, 2007·Journal of Agricultural and Food Chemistry·Malgorzata StrekElzbieta Hrabec
Dec 15, 2007·Molecular Nutrition & Food Research·Min-Hsiung PanChi-Tang Ho
Jan 15, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J-P LavigneA Sotto
Jun 19, 2008·Journal of Agricultural and Food Chemistry·Joe A VinsonNajwa Samman
Jun 24, 2008·The Journal of Nutrition·Daniela GalloGiovanni Scambia
Aug 1, 2008·Cellular and Molecular Life Sciences : CMLS·M Krishna, H Narang
Jan 16, 2009·Journal of Gastroenterology and Hepatology·Masashi MatsushimaTetsuya Mine
Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nichole R DeanEben L Rosenthal
Jul 31, 2009·Journal of Dental Research·V D LaD Grenier

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Citations

Aug 18, 2010·Cancer Metastasis Reviews·Michael J WargovichRebecca Weber
Oct 7, 2011·Journal of Oncology·William W LiAlbert S Chiou
Sep 23, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hana BártíkováBarbora Szotáková
Nov 6, 2013·Critical Reviews in Food Science and Nutrition·Francesc PuiggròsLluís Arola
Sep 13, 2011·Journal of the Science of Food and Agriculture·Catherine C Neto
Jul 7, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wilson Maldonado-Rojas, Jesus Olivero-Verbel
Jan 20, 2018·Cancer Causes & Control : CCC·Delphine PraudMarta Rossi
Jul 6, 2019·Anti-cancer Agents in Medicinal Chemistry·Maria MantzorouConstantinos Giaginis

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