Proapoptotic and antiapoptotic effects of hyperglycemia: role of insulin signaling

Canadian Journal of Physiology and Pharmacology
Craig RicciStephen W Schaffer

Abstract

Glucose toxicity is an important initiator of cardiovascular disease, contributing to the development of insulin resistance, impaired contractile function, abnormal energy metabolism, cardiomyocyte and endothelial cell death, coronary heart disease, and heart failure. High blood glucose can, however, paradoxically protect the heart against a variety of insults, including ischemia, hypoxia, and calcium overload. To provide information on the underlying basis of these divergent actions of high glucose, the present study examined the hypothesis that the adverse effects of high glucose are linked to impaired insulin signaling, leading to a reduction in the levels of cytoprotective factors, and that the beneficial effects of high glucose occur in the absence of insulin and result in an improvement in Akt signaling. This hypothesis was evaluated by using an in vitro cardiomyocyte model that is amenable to manipulations in glucose and insulin. Prolonged exposure of the isolated neonatal cardiomyocyte to medium containing insulin and high glucose led to increased susceptibility to angiotensin II-mediated apoptosis, an effect associated with reduced levels of phospho-Akt and an increased Bax/Bcl-2 ratio. By contrast, exposure to high gl...Continue Reading

References

Feb 7, 2001·The Journal of Biological Chemistry·S PugazhenthiJ E Reusch
Apr 26, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·F FiordalisoJ Kajstura
Nov 18, 2000·Circulation·D A Cooley, O H Frazier
Jan 11, 2000·Circulation Research·A FrustaciP Anversa
Feb 14, 2002·The Journal of Biological Chemistry·Fuminori TsurutaYukiko Gotoh
Oct 14, 2003·Cardiovascular Toxicology·Lu Cai, Y James Kang
Nov 10, 2004·Molecular and Cellular Biochemistry·Amy J DavidoffJun Ren
Dec 15, 2004·Biochemical and Biophysical Research Communications·Xia XiJin-Zhong Zhang
Jan 18, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Meei Ling SheuShing-Hwa Liu
Jul 12, 2005·The Journal of Clinical Investigation·Tomohisa NagoshiAnthony Rosenzweig
Oct 29, 2005·Metabolism: Clinical and Experimental·Wen YeshaoJerry L Nadler
Aug 11, 2006·American Journal of Physiology. Cell Physiology·Voraratt ChampattanachaiJohn C Chatham
Jul 7, 2007·Canadian Journal of Physiology and Pharmacology·Craig RicciStephen W Schaffer

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Citations

Mar 13, 2009·Cardiovascular Research·Shigeki MiyamotoMark A Sussman
May 28, 2010·American Journal of Physiology. Cell Physiology·Viktor PastukhStephen W Schaffer
Oct 24, 2009·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·J Claudio GutierrezSteven D Holladay
Jul 16, 2010·Molecular and Cellular Biochemistry·Radhakrishnan SelviSrinivasan Vidhya
Jan 1, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sung Yeon HamYon Hee Shim
Jul 31, 2021·Frontiers in Endocrinology·Elite PossikMarc Prentki
Apr 13, 2011·Molecular Immunology·Paola I IngaramoCristina E Carnovale

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