Abstract
In cutaneous T-cell lymphoma (CTCL) lesions, both reactive T cells and malignant T cells intermingle. The disease progression is mostly slow. Recent evidence suggests that even if clinical remission is reached, malignant cells persist and a relapse follows sooner or later. To wha extent tumour cell apoptosis occurs in the skin lesions either due to the reactive T cells or t therapeutic efforts is not known. To determine the extent of tumour cell apoptosis and the expression of proapoptotic an antiapoptotic markers in serial skin lesion samples from patients with CTCL, and to compare th findings with those in patients with lymphomatoid papulosis (LyP). Thirty-four skin samples were obtained from 12 patients with CTCL at the time o diagnosis and at a mean of 1.6, 3 and 6 years later. The patients received psoralen plus ultraviolet (PUVA), electron beam or cytostatic treatments. In addition, fresh post-treatment samples fro three patients with CTCL undergoing PUVA therapy were obtained. For comparison, skin biopsies o five patients with LyP were studied. Immunohistochemical demonstration of the expression of th following markers was performed on formalin-fixed skin sections: Fas (CD95), Fas ligand (FasL) bcl-2, granzyme B, the tum...Continue Reading
References
Jan 1, 1968·Archives of Dermatology·W L Macaulay
Mar 1, 1995·Leukemia & Lymphoma·M J RobertsonJ Ritz
Jul 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J T WolfeS R Lessin
Jul 1, 1995·The Journal of Investigative Dermatology·G S WoodA Z Uluer
Apr 1, 1995·Clinical and Experimental Immunology·J A KummerC E Hack
Feb 1, 1995·Journal of Cutaneous Pathology·R DummerG S Wood
Sep 1, 1994·Pathology, Research and Practice·P KanavarosA Tosca
Apr 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T PatelS H Kaufmann
Aug 1, 1996·The Journal of Investigative Dermatology·E K YooB R Vowels
Feb 7, 1997·Cell·S Nagata
Mar 28, 1997·Science·J LiR Parsons
Jul 1, 1997·Archives of Dermatology·A Kikuchi, T Nishikawa
Sep 1, 1997·The Journal of Clinical Investigation·S StollJ Elder
Oct 23, 1997·Journal of Cutaneous Pathology·C W van HaselenR Willemze
Nov 5, 1997·Genomics·X P Zhao, J T Elder
Jan 14, 1998·Nature Medicine·A Strasser, L O'Connor
Feb 14, 1998·Nature Medicine·B JansenH Pehamberger
Sep 12, 1998·Science·J M Adams, S Cory
Dec 5, 1998·The Journal of Biological Chemistry·S K Manna, B B Aggarwal
Feb 5, 1999·Human Molecular Genetics·P L DahiaC Eng
May 11, 1999·The American Journal of Pathology·M H VermeerR Willemze
Feb 15, 2000·Histopathology·M L BoullandP Gaulard
May 10, 2000·Nature Medicine·N P Restifo
Jun 9, 2000·Clinical and Experimental Immunology·M CarbonariM Fiorilli
Jul 8, 2000·The Journal of Investigative Dermatology·H EchchakirF Mami-Chouaib
Aug 22, 2000·The British Journal of Dermatology·O Zoi-ToliR Willemze
Dec 21, 2000·The British Journal of Dermatology·O DereureJ J Guilhou
Feb 13, 2001·The Journal of Investigative Dermatology·L KarenkoA Ranki
Citations
May 5, 2006·Annals of Hematology·Jin Tae JungKyu Bo Lee
Feb 9, 2012·Current Treatment Options in Oncology·Tara BloomSteven T Rosen
Mar 16, 2005·The American Journal of Surgical Pathology·Loren E ClarkeKlaus F Helm
Jun 17, 2006·Blood·Paula V CabreraLinda G Baum
Oct 4, 2008·Blood·Remco van DoornCornelis P Tensen
Jan 29, 2011·Blood·Yang WangYouwen Zhou
Aug 14, 2012·Journal of the American Academy of Dermatology·Nathalie StutzGary S Wood
Oct 17, 2008·The Journal of Investigative Dermatology·Jianqiang WuGary S Wood
Oct 16, 2004·Journal of the European Academy of Dermatology and Venereology : JEADV·M Aguilar-BernierA Miranda-Romero
Jun 14, 2005·The British Journal of Dermatology·S BrennandH M Prince
Apr 28, 2005·Experimental Dermatology·Johannes GreisserWerner Kempf
May 9, 2007·The British Journal of Dermatology·G GoteriL Lomuzio
Apr 29, 2006·European Journal of Cancer Care·S LaubeJ Marsden
Nov 4, 2006·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Günter BurgReinhard Dummer
Apr 23, 2010·The British Journal of Dermatology·K FerencziK D Cooper
Sep 28, 2012·The British Journal of Dermatology·T ShimauchiY Tokura
Apr 27, 2010·Photodermatology, Photoimmunology & Photomedicine·Hani WeshahyAli Hindawi
Mar 29, 2014·Proteomics. Clinical Applications·Lars T Joeckel, Phillip I Bird
Dec 25, 2002·The Tohoku Journal of Experimental Medicine·Zuhal HamurcuEkrem Aktas
Dec 18, 2013·Cell Cycle·Minakshi NihalGary S Wood
Dec 9, 2016·Cell Cycle·Karthik M KodigepalliLi Wu
Jun 3, 2015·Journal of Cutaneous Medicine and Surgery·Amira El TawdyZeiad Gad
Nov 15, 2007·Cytogenetic and Genome Research·L KarenkoA Ranki
Sep 30, 2021·Molecular Cancer·Katharina RindlerPatrick M Brunner